The Anthelmintic Activity of Eupatorium triplinerve and Alpinia galanga in Pheritima posthuma and Ascardia galli: A Comparative Study 947-950
Dr. K.R. Subash
Department of Pharmacology,
Meenakshi Medical College & research institute,
MAHER, Kanchipuram - 631552 (India).
Aim: The ethanolic extracts from the leaves of Eupatorium triplinerve and the rhizome of Alpinia galanga were compared for their anthelmintic activities, based on traditional claims.
Methods: Pheritima posthuma and Ascardia galli were used as the suitable in vitro models; the time which was taken for paralysis (P) and death (D) were used as the parameters to assess their anthelmintic activities, with Albendazole 50mg/ml as the standard.
Results: Eupatorium triplinerve exhibited a dose dependent anthelmintic activity in both the models at the concentrations of 50mg/ml and 100mg/ml, thus indicating a broad spectrum of action, whereas Alpinia galanga, as compared to Eupatorium triplinerve, failed to show any activity against Pheritima posthuma, but exhibited a potent activity in a dose dependent manner which was comparable to that of the standard, albendazole 23.00 + 2.60(P), 63.33 + 2.33(D) at a 100mg/ml concentration against Ascardia galli at minutes 32.83 + 4.07(P) and 69.33 + 3.93.