Peptiduria in patients with acute renal failure 196-200
Dr Mungli Prakash, MD
Department of Biochemistry and Genetics,
St Matthew’s University, School of medicine,
P.O.Box 30992, Regatta Office Park, Leeward Three
Grand Cayman KY 1-1204,
Cayman Islands, BWI.
Telephone: 345-814-3187 (office)
Introduction: Proteinuria is a common finding in acute renal failure (ARF). Recently, there is an increasing interest in knowing the significance of peptiduria in renal failure patients. The current study has been undertaken to know the levels of peptiduria in ARF patients.
Method: 58 ARF patients and 55 healthy controls were selected, based on inclusion and exclusion criteria. Urinary proteins and peptide levels were determined by the spectrophotometer based Lowry and Bradford methods.
Results: The urinary %s of peptides in urine were significantly decreased in ARF patients; there was a wide variation in thelevels of peptides in grams per liter of urine and in the levels of peptides in grams per gram of creatinine. Urine creatinine levels correlated positively with the urinary peptide levels.
Conclusion: ARF patients showed a significant decrease in the %s of urinary peptides and the %s of the urinary peptides seemed to be a more appropriate measure in determining the levels of urinary peptides. To study the significance of urinary peptides in the diagnosis and management of ARF needs future research in this field.