Top of Basilar Artery Syndrome
Pokhraj P. Suthar1, Prakash J. Rana2, Chetan Mehta3, Narottam A. Patel4
1Resident Doctor, Department of Radiology, Medical College, Baroda, Gujarat, India.
2Resident Doctor, Department of Radiology, S.S.G. Hospital, Medical College, Vadodara, India.
3Associate Professor, Department of Radiology, S.S.G. Hospital, Medical College, Vadodara, India.
4Professor, Department of Radiology, S.S.G. Hospital, Medical College, Vadodara, India.
NAME, ADDRESS, E-MAIL ID OF THE CORRESPONDING AUTHOR: Dr. Suthar Pokhraj P, Pokhraj Prakashchandra Suthar, 5-Durga Nagar Society, Karodiya, Baroda, Gujarat, India.
E-mail: pokhraj_suthar@yahoo.co.in
A 45 years old male presented in Department of Medicine at the Shree Shayaji General Hospital with sudden onset bilateral ptosis, dilatation of the pupil and paresis of extraocular muscles. There were area of restricted diffusion on diffusion weighted images with corresponding low ADC (Apparent Diffusion Coefficient) value in periaqueductal region, oculomotor nucleus and medial thalami suggestive of acute infract. In MR cerebral angiographic image filling defect is seen in the basilar artery suggestive of thrombosis [Table/Fig-1,2,3]. Top of the Basilar Artery Syndrome is also known as a Rostral Brainstem Infarction. It is due to the thromboembolic occlusion of the top of the basilar artery. Risk factors for the thrombosis are hypertension [1], diabetes mellitus [2], obesity [2], hyperhomocystinemia [3], and excessive alcohol intake. It may be secondary to the cardiogenic emboli like mural thrombi in myocardial infarction and atrial fibrillations or valvular thrombi in infective endocarditic and valvular heart disease. Hypercoaguable states like antiphospholipid antibodies [4], protein C deficiency [4], protein S deficiency [4] may also leads to the thrombotic events. Small vessel vaculities in sickle cell disease may be associated with it. Bilateral tha lamic ischemia occurs due to occlusion of perforator vessels. Clinically patient develops symptoms like visual and oculomotor deficits and behavioral abnormalities. However, motor dysfunction is often absent [5]. CT angiography, MR angiography and catheter angiographic are the imaging modality use to confirm the finding and demonstrate a filling defect [6]. Prognosis in patient with bilateral ocular palsy is poor.
Top of the basilar artery syndrome is occurring due to thrombotic occlusion of the basilar artery. Patient presented with visual and oculomotor deficit and behaviour abnormalities. MR angiography demonstrate filling defect in the basilar artery.
Axial section of diffusion weighted MR image shows (A) area of restricted diffusion in oculomotor nuclei region in midbrain (open white arrow) (B) area of restricted diffusion in bilateral medial thalami (open white arrow)
Axial section of Apparent Diffusion map shows (A) corresponding low ADC value in oculomotor nuclei region in medulla (black solid arrow) (B) in bilateral medial thalami (solid white arrow)
MR angiographic images shows filling defect in the basilar artery suggestive of thrombosis
[1]. F Turnbull, Blood pressure lowering treatment trialists' collaboration. Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials Lancet 2003 362(9395):1527-35. [Google Scholar]
[2]. E Previtali, P Bucciarelli, SM Passamonti, I Martinelli, Risk factors for venous and arterial thrombosis Blood Transfusion 2011 9(2):120-38.doi:10.2450/2010.0066-10 [Google Scholar]
[3]. M Cattaneo, Hyperhomocysteinemia, atherosclerosis and thrombosis Thromb Haemost 1999 81(2):165-76. [Google Scholar]
[4]. DA Lane, H Philippou, JA Huntingtonn, Directing thrombin Blood 2005 106(8):2605-12. [Google Scholar]
[5]. LR Caplan, "Top of the basilar" syndrome Neurology 1980 30(1):72-79. [Google Scholar]
[6]. F Barkhof, J Valk, "Top of the basilar" syndrome: a comparison of clinical and MR findings Neuroradiology 1988 30(4):293-98. [Google Scholar]