Others Section DOI : 10.7860/JCDR/2019/41971.13086
Year : 2019 | Month : Aug | Volume : 13 | Issue : 08 Page : OC25 - OC27

Comparison of Pulmonary Function in Children with Cerebral Palsy and Normally Developed Children

Sandeep Kumar Gupt1, Diganta Borah2, BD Athani3

1 Senior Resident, Department of Physical Medicine and Rehabilitation, AIIMS, Bhopal, India.
2 Professor, Department of Physical Medicine and Rehabilitation, VMMC and Safdarjung Hospital, New Delhi, India.
3 Principal Consultant, Department of Physical Medicine and Rehabilitation, VMMC and Safdarjung Hospital, New Delhi, India.


NAME, ADDRESS, E-MAIL ID OF THE CORRESPONDING AUTHOR: Dr. Diganta Borah, Professor, Department of Physical Medicine and Rehabilitation, VMMC and Safdarjung Hospital, New Delhi-110029, India.
E-mail: diganta29@yahoo.com
Abstract

Introduction

Cerebral Palsy is one of the most common neurological disorders in children. It is characterised by varying degrees of disability affecting multiple domains. Respiratory complications, especially in severely disabled cerebral palsy patients are a major cause of morbidity and mortality. However, respiratory deficiencies in children with cerebral palsy is often overlooked and rarely assessed in the clinical setting.

Aim

To assess the pulmonary function in children with cerebral palsy and compare the same with normally developed children.

Materials and Methods

Thirty seven patients diagnosed with spastic cerebral palsy in the age range of 5-18 years and 37 age matched normally developed controls were enrolled. Assessment of pulmonary function in terms of Forced Vital Capacity (FVC), Forced Expiratory Volume in 1st divond, FEV1/FVC, Peak Expiratory Flow (PEF), Forced expiratory flow over 25-75% of FVC (FEF25-75), Inspiratory Reserve Volume (IRV), Expiratory Reserve Volume (ERV), Tidal Volume (TV) and Vital Capacity (VC) was done for each subject. Statistical analysis was done using SPSS version 21.0 and a p-value of <0.05 was considered as statistically significant.

Results

Most of the children with cerebral palsy were found to have lower FVC, FEV1, PEF25-75, IRV, ERV, TV and VC in comparison to normally developed children indicative of predominantly restrictive pulmonary pathology.

Conclusion

Routine pulmonary function testing in cerebral palsy children may reveal compromised pulmonary function. This will enable early therapeutic intervention for management of respiratory dysfunction in these children.

Introduction

Cerebral Palsy is one of the most common neurological disorders encountered in paediatric population affecting 2-3 per 1000 live births [1,2]. It is due to non-progressive disturbances in the developing foetal or infant brain which results in a set of permanent developmental disorders of movement and posture. Although motor disorders are predominant, they are often accompanied by disturbances of sensation, perception, cognition, communication and behaviour. Epilepsy and secondary musculoskeletal problems are also frequently encountered leading to varying degree of disability [3,4].

Owing to this wide spectrum of abnormalities, cerebral palsy is rendered one of the most common causes of childhood disability. Restricted mobility and the afore-mentioned abnormalities in sensation, perception, cognition, communication, behaviour and other neurological conditions like seizures make cerebral palsy patients vulnerable to respiratory complications. Respiratory compromise may further be augmented by associated upper airway obstruction due to inadequate nasopharyngeal motor function, obstructive sleep apnoea syndrome or poor nutrition [5-7]. Respiratory complications, especially in severely disabled cerebral palsy patients are reported to be a major cause of morbidity and mortality and are a matter of great concern [8-14].

However, despite presence of evidence, not much attention is directed towards evaluation of respiratory deficiencies in children with cerebral palsy. This study has been designed to address this issue with an aim to compare pulmonary functions in children with cerebral palsy and normally developed children.

Materials and Methods

This cross-sectional comparative study was conducted in Department of Physical Medicine and Rehabilitation of a tertiary care hospital during the period from October 2013 to February 2015. Ethical approval was taken before initiating the study (S.No. IEC/VMMC/SJH/Thesis/Oct-13/152).

Thirty seven patients with spastic cerebral palsy diagnosed on the basis of history and clinical findings, within the age range of 5-18 years of either gender (Group 1), were included in the study. Thirty seven age matched normally developed controls (Group 2) of both genders were enrolled from the relatives of the children with cerebral palsy and children attending Physical Medicine and Rehabilitation OPD for other problems. Written informed consent was taken from parents/guardians of all participants. The sample size was calculated based on a study by Kwon YH et al., comparing respiratory functions of CP children with normally developed children [15].

Children with mental retardation, apparent chest deformity and Gross Motor Function Classification System (GMFCS) 4, 5 were excluded from study. Subjects were thoroughly examined clinically after obtaining detailed medical history from participants/parents using the study proforma.

Demographic characteristics recorded were age, sex, residence, and socio-economic status. Assessment of pulmonary function was done by using computerised Medisoft spiro air spirometer. Clear instruction regarding the procedure was given to all the participants. They were first accustomed to the apparatus and the procedure, following which a minimum of three readings were taken for each parameter. The assessment parameters recorded were FVC, FEV1, FEV1/FVC, PEF, FEF25-75, IRV, ERV, TV and VC.

Statistical Analysis

Data collected were entered into Microsoft Excel spread sheet and analysed using SPSS version 21.0 software. Categorical data was presented in number and percentage and continuous variables were presented as mean±SD. Normality of data was tested by Kolmogorov-Smirnov test. Quantitative variables were compared using Unpaired t-test/Mann-Whitney test and qualitative variables were compared using Chi-square test and Fisher’s-exact test. A p-value <0.05 was considered as statistically significant.

Results

Seventy-four children, 37 with spastic cerebral palsy (Group 1) and 37 normally developed children (Group 2) were enrolled in study. The two groups were comparable with respect to demographic characteristics [Table/Fig-1]. In group 1, 18 (49%) children were spastic hemiplegic and 19 (51%) were spastic diplegic. Among the spastic hemiplegic children, 12 were right and 6 were left sided hemiplegic.

Demographic characteristics of the children.

Baseline characteristicsGroup 1 (n=37)Group 2 (n=37)p-value
Mean age in years11.24±3.4312.16±2.720.234
Mean height in centimetre139±17.31143.11±13.140.207
Mean weight in kilogram32.95±10.9536.16±10.780.355
Gender distributionMale=27 Female=10Male=29 Female=80.588

[Table/Fig-2,3] shows the observed values of different parameters used for assessment of pulmonary function. Significant difference between the two groups was found in FVC. All the children in group 1 had decreased FVC while in group 2 only one child had so. Two children in group 1 were found to have normal FEV1 while in group 2, seven children had decreased FEV1. This difference in FEV1 between the two groups is statistically significant. While comparing the ratio of FEV1 and FVC significant difference was observed between the two groups. Decreased PEF was found in 24 group 1 children and 9 in group 2 children had normal, while, FEF over middle of FVC was found to be decreased in 28 children in group 1 and 22 in group 2. The mean IRV and ERV of group 1 child was found to be significantly lower than that of group of 2 children. Tidal volume of group 1 children ranged from 0.15 to 0.78 litres while in group 2 children the same was from 0.35 to 0.81. While comparing the mean tidal volumes, the difference between the two groups was found to be significant. Only two children in group 1 had normal vital capacity. 35 children in group 1 were found to have decreased vital capacity, while only three children in group 2 showed so.

The flow rates and vital capacity of the children.

ParametersAs compared to predictive valueGroup 1 (n=37)Group 2 (n=37)p-value
FVCDecreased371<0.001
Normal034
Increased02
FEV1Decreased357<0.001
Normal228
Increased02
FVC/FEV1Normal1127<0.001
Increased2610
PEFDecreased242<0.001
Normal129
Increased120
FEF 25-75Decreased28220.007
Normal69
Increased36
VCDecreased353<0.001
Normal230
Increased04

Different lung volumes of the children.

ParametersGroup 1 (n=37)Group 2 (n=37)p-value
Mean IRV (litre)0.61±0.40.96±0.44<0.0001
Mean ERV (litre)0.53±0.310.94±0.53<0.0001
Mean TV (litre)0.46±0.150.53±0.10.037

Thus, observed results indicate significantly compromised respiratory function in spastic CP children as compared to children with normal development.

The observed pulmonary function of the children in the group 1 were further analysed for type of dysfunction. Out of 37 children included in the group 1, 28 (75.68%) children were found to have restrictive type of lung dysfunction, 8 (21.7%) showed obstructive type of lung dysfunction and 1 (2.7%) child showed non-conclusive parameters.

Discussion

Cerebral palsy is a common cause of physical disability in children. Respiratory infection and diminished pulmonary function rank as one of the chief causes of morbidity and mortality [16]. In this study we assessed and compared pulmonary function among children with spastic cerebral palsy with normally developed children. Results of the study revealed compromised pulmonary function in the cerebral palsy group. The difference in FVC, FEV1 and FEV1/FVC ratio between the patient group and control was statistically significant. The peak and mid expiratory flow rates, vital capacity, tidal volume, expiratory and inspiratory reserve volumes were also found to be decreased in cerebral palsy group. However, out of these flow rates and static lung volumes, tidal volume failed to show statistically significant difference between the two groups. These findings are in accordance with previous studies, which reported significantly poorer pulmonary function in children with cerebral palsy as compared to normally developed cerebral palsy children [15-17].

The results of the pulmonary function tests are indicative of restrictive dysfunction in these children, in spite of the fact that cerebral palsy children with obvious structural deformities of the chest were excluded from the study. The observed difference between the two groups can be attributed to a decrease in physical activity and chest mobility caused by motor disability in these children. Ersoz M et al., reported that children with cerebral palsy had restricted chest mobility which mainly resulted from muscle weakness, spasticity, and impaired neuro-motor control rather than involvement of costo-vertebral joint movement [18]. Muscle weakness may further be affected by decreased physical activity. It is possible that low level of physical activity and trunk control is accompanied by a decrease of respiratory function, which leads to deterioration of lung expansion by restriction of chest mobility. Restrictive lung diseases mainly result from impairment of the elastic properties of the lungs and chest wall and are characterised by reduced lung volumes and capacities. Deformities of spine and thorax are often encountered [19-21]. Also, individuals with neuromotor impairment rely on abdominal muscles for respiration showing poorly coordinated breathing [22,23]. Gradually chest movements become restricted and muscles are weakened. Eventually, the ability to take deep breath, generate expiratory force, and cough effectively is impaired [24]. These children are therefore more prone to develop respiratory infections. Although a matter of serious concern, respiratory problems in cerebral palsy has not received due attention in the clinical setting and pulmonary function test are not done routinely. Only a few studies comparing pulmonary function in cerebral palsy children with normal children have been reported in the literature. But, most studies have reported impaired pulmonary function in cerebral palsy children mostly of the restricted variety. The present study highlights the fact that simple measurement of pulmonary function can help in administration of timely rehabilitative/preventive measures that can greatly reduce morbidity and mortality in these children. Prevention of mucus stasis is of utmost importance and should be the principal focus of respiratory management for children with cerebral palsy. Exercise programs that encourage deep breathing, increase airflow rates, and stimulate cough may enhance secretion clearance. Application of pulmonary rehabilitation is important for children with cerebral palsy who have pulmonary dysfunction in order to reduce morbidity and to improve quality of life.

The findings of this study provide rationale for early clinical assessment, prevention and rehabilitative intervention for management and treatment of diverse pulmonary diseases in children with cerebral palsy.

Limitation

The major limitation of this study is difficulty in extrapolation due to small sample size and difficulty in performing PFT in non-cooperative children. In addition, we did not consider a variety of clinical factors related to pulmonary function in terms of oxygen saturation, chest wall excursion, etc. So, further study of overall pulmonary function including these factors will be needed.

Conclusion

Routine pulmonary function testing in cerebral palsy children will provide insight into aberration in respiratory function and help in introducing timely rehabilitative measures and is an invaluable tool for assessment of pulmonary function. In total, 75.68% of the cerebral palsy children showed restrictive type of pulmonary dysfunction. Significantly, lower pulmonary function in children with cerebral palsy compared to normal children. Early clinical assessment and therapeutic intervention for respiratory function should be carefully considered for children with cerebral palsy.

References

[1]Odding E, Roebroeck ME, Stam HJ, The epidemiology of cerebral palsy: Incidence, impairments and risk factors Disability and Rehabilitation 2006 28(4):183-91.10.1080/0963828050015842216467053  [Google Scholar]  [CrossRef]  [PubMed]

[2]Krageloh-Mann I, Cans C, Cerebral palsy update Brain Dev 2009 31:537-44.10.1016/j.braindev.2009.03.00919386453  [Google Scholar]  [CrossRef]  [PubMed]

[3]Cooper MS, Mackay MT, Fahey M, Reddihough D, Reid SM, Williams K, Seizures in children with cerebral palsy and white matter injury Pediatrics 2017 139(3):e2016297510.1542/peds.2016-297528209769  [Google Scholar]  [CrossRef]  [PubMed]

[4]Rosenbaum P, Paneth N, Leviton A, Goldstein M, Bax M, Damiano D, A Report: The definition and classification of cerebral palsy April 2006 Dev Med Child Neurol 2007 49(s109):8-14.  [Google Scholar]

[5]Wilkinson DJ, Baikie G, Berkowitz RG, Reddihough DS, Awake upper airway obstruction in children with spastic quadriplegic cerebral palsy J Paediatr Child Health 2006 42(1-2):44-48.10.1111/j.1440-1754.2006.00787.x16487389  [Google Scholar]  [CrossRef]  [PubMed]

[6]Strauss D, Brooks J, Rosenbloom L, Shavelle R, Life expectancy in cerebral palsy: an update Dev Med Child Neurol 2008 50(7):487-93.10.1111/j.1469-8749.2008.03000.x18611196  [Google Scholar]  [CrossRef]  [PubMed]

[7]Seddon PC, Khan Y, Respiratory problems in children with neurological impairment Arch Dis Child 2003 88(1):75-78.10.1136/adc.88.1.7512495971  [Google Scholar]  [CrossRef]  [PubMed]

[8]Meehan E, Reid SM, Williams K, Freed GL, Sewell JR, Vidmar S, Hospital admissions in children with cerebral palsy: A data linkage study Dev Med Child Neurol 2017 59:512-19.10.1111/dmcn.1335027900776  [Google Scholar]  [CrossRef]  [PubMed]

[9]Blackmore AM, Bear N, Blair E, Langdon K, Moshovis L, Steer K, Predicting respiratory hospital admissions in young people with cerebral palsy Arch Dis Child 2018 103:1119-24.10.1136/archdischild-2017-31434629555725  [Google Scholar]  [CrossRef]  [PubMed]

[10]Evans PM, Alberman E, Certified cause of death in children and young adults with cerebral palsy Arch Dis Child 1991 66(3):325-29.10.1136/adc.66.3.325  [Google Scholar]  [CrossRef]

[11]Maudsley G, Hutton JL, Pharoah PO, Cause of death in cerebral palsy: A descriptive study Arch Dis Child 1999 81(5):390-94.10.1136/adc.81.5.390  [Google Scholar]  [CrossRef]

[12]Hutton JL, Colver AF, Mackie PC, Effect of severity of disability on survival in north east England cerebral palsy cohort Arch Dis Child 2000 83(6):468-74.10.1136/adc.83.6.46811087278  [Google Scholar]  [CrossRef]  [PubMed]

[13]Reddihough DS, Baikie G, Walstab JE, Cerebral palsy in Victoria, Australia: mortality and causes of death J Paediatr Child Health 2001 37(2):183-86.10.1046/j.1440-1754.2001.00644.x11328476  [Google Scholar]  [CrossRef]  [PubMed]

[14]Duruflé-Tapin A, Colin A, Nicolas B, Lebreton C, Dauvergne F, Gallien P, Analysis of the medical causes of death in cerebral palsy Ann Phys Rehabil Med 2014 57(1):24-37.10.1016/j.rehab.2013.11.00224341986  [Google Scholar]  [CrossRef]  [PubMed]

[15]Kwon YH, Lee HY, Differences of respiratory function in children with spastic diplegic and hemiplegic cerebral palsy, compared with normally developed children J Pediatr Rehabil Med 2013 6(2):113-17.10.3233/PRM-13024623803344  [Google Scholar]  [CrossRef]  [PubMed]

[16]Evans PM, Evans SJW, Alberman E, Cerebral palsies: why we must plan for survival Arch Dis Child 1990 65(12):1329-33.10.1136/adc.65.12.13292148667  [Google Scholar]  [CrossRef]  [PubMed]

[17]Wang HY, Chen CC, Hsiao SF, Relationships between respiratory muscle strength and daily living function in children with cerebral palsy Res Dev Disabil 2012 33(4):1176-82.10.1016/j.ridd.2012.02.00422502843  [Google Scholar]  [CrossRef]  [PubMed]

[18]Ersoz M, Selcuk B, Gunduz R, Kurtaran A, Akyuz M, Decreased chest mobility in children with spastic cerebral palsy Turk J Pediatr 2006 48(4):344-50.  [Google Scholar]

[19]Yazici M, Şenaran H, Cerebral palsy and spinal deformities Acta Orthop Traumatol Turc 2009 43(2):149-55.10.3944/AOTT.2009.14919448355  [Google Scholar]  [CrossRef]  [PubMed]

[20]Hägglund G, Pettersson K, Czuba T, Persson-Bunke M, Rodby-Bousquet E, Incidence of scoliosis in cerebral palsy Acta Orthopaedica 2018 89(4):443-47.10.1080/17453674.2018.145009129537343  [Google Scholar]  [CrossRef]  [PubMed]

[21]Koop SE, Scoliosis in cerebral palsy Dev Med Child Neurol 2009 51(s4):92-98.10.1111/j.1469-8749.2009.03461.x19740215  [Google Scholar]  [CrossRef]  [PubMed]

[22]Dias RC, Miller F, Dabney K, Lipton GE, Revision spine surgery in children with cerebral palsy J Spinal Disord 1997 10(2):132-44.10.1097/00002517-199704000-000069113612  [Google Scholar]  [CrossRef]  [PubMed]

[23]Benditt JO, Management of pulmonary complications in neuromuscular disease Phys Med Rehabil Clin N Am 1998 9(1):167-85.10.1016/S1047-9651(18)30285-7  [Google Scholar]  [CrossRef]

[24]McCool FD, Leith DE, Pathophysiology of cough Clin Chest Med 1987 8(2):189-95.  [Google Scholar]