Anaesthesia Section DOI : 10.7860/JCDR/2017/27020.10578
Year : 2017 | Month : Sep | Volume : 11 | Issue : 9 Page : UC04 - UC08

Comparative Study of the Effect of Dexmedetomidine Vs. Fentanyl on Haemodynamic Response in Patients Undergoing Elective Laparoscopic Surgery

Jayshree P Vaswani1, Debasis Debata2, Varsha Vyas3, Surekha Pattil4

1 Professor, Department of Anaesthesia, Padmashree Dr D.Y Patil Medical College, Navi Mumbai, Maharashtra, India.
2 Senior Resident, Department of Anaesthesia, Padmashree Dr D.Y Patil Medical College, Navi Mumbai, Maharashtra, India.
3 Associate Professor, Department of Anaesthesia, Padmashree Dr D.Y Patil Medical College, Navi Mumbai, Maharashtra, India.
4 Professor, Department of Anaesthesia, Padmashree Dr D.Y Patil Medical College, Navi Mumbai, Maharashtra, India.


NAME, ADDRESS, E-MAIL ID OF THE CORRESPONDING AUTHOR: Dr. Debasis Debata, CDA, SEC-6, Plot-C-1329 P.O-Abhinav Bidanasi, Cuttack-753014, Odisha, India.
E-mail: debasisdebata@gmail.com
Abstract

Introduction

Dexmedetomidine and fentanyl, both have sedative and analgesic effects. They are often used as adjunct during anaesthesia to attenuate pressor response during tracheal intubation. Limited study has been done comparing the effect of both drugs on haemodynamic response in patients undergoing laparoscopic surgery.

Aim

The study was designed to compare the effect of dexmedetomidine Vs fentanyl on haemodynamic response to tracheal intubation, following pneumoperitoneum and intraoperative period in patients undergoing laparoscopic surgery.

Materials and Methods

Sixty patients of age group 18-60 years of either sex, classified as American Society of Anaesthesiologist (ASA) Grade I and II undergoing elective laparoscopy surgery were randomly allocated to one of the two groups (Group-D) and (Group F) of 30 each. Group D received dexmedetomidine and Group F received fentanyl. Patients received intravenous 0.5 μg/kg of the study drug as loading dose over 10 minutes prior to intubation followed by 0.2-0.7 μg/kg/hr as infusion till surgery was over. In operating room parameters like Heart Rate (HR), Respiratory Rate (RR), Systolic Blood Pressure (SBP), Mean Arterial Pressure (MAP), SpO2, EtCO2 were recorded 10 minutes after infusion of drug i.e., dexmedetomidine or fentanyl. The said parameters were again recorded after injection of induction drugs, after intubation, five minutes after intubation, just after pneumoperitoneum, and 5,10,15,30,45 and 60 minutes after pneumoperitoneum, five minutes after release of pneumoperitoneum, five and 10 minutes after extubation.

Results

Dexmedetomidine significantly attenuates stress response at intubation with lesser increase in HR (5% Vs 18%), SBP (9% Vs 19%) and DBP (3% Vs 15%), MAP (2% Vs 15%) as compared to fentanyl (p<0.05). Throughout intraoperative period of pneumoperitoneum Group D showed significant fall in HR, SBP, DBP, MAP from baseline value at all points of time intervals whereas it remained constantly high above baseline value in Group F (p-value <0.05).

Conclusion

Dexmedetomidine when compared to fentanyl causes greater attenuation of stress response to tracheal intubation, following pneumoperitoneum and in intraoperative period resulting in greater reduction of HR, SBP, DBP, MAP than that of fentanyl, thus causing better haemodynamic stability in patients undergoing elective laparoscopic surgery.

Introduction

Laparoscopic surgeries are becoming popular due to several postoperative benefits allowing quicker recovery, less tissue damage, avoiding big surgical incision, shorter hospital stay with consequent reduction in health care cost [1].

But anaesthetic management in these patients has become complicated due to cardiopulmonary changes occuring during creation of pneumoperitoneum with CO2 and patient position required for different laparascopic surgeries. Laryngoscopy, tracheal intubation and pneumoperitoneum are associated with sympathetically mediated adverse haemodynamic effect like elevation of arterial pressure, heart rate, decrease in cardiac output due to pneumoperitoneum and increase of systemic and pulmonary vascular resistances. Peritoneal insufflations also results in ventilatory and respiratory changes and can contribute to stress response [2,3].

Many studies have been done using α2 adrenergic agonist compounds like clonidine as premedicant in laparoscopic surgeries [4-6]. Newer drug like dexmedetomidine shows a high ratio of specificity (α2/α1 1620:1) making it a complete α2 agonist [7]. When used as an adjuvant it attenuates stress response associated with anaesthesia and surgery providing haemodynamic stability without significant respiratory depression [8]. It has the ability to sedate and provide analgesia while maintaining patient’s arousability and respiratory function.

Fentanyl citrate is a narcotic analgesic interacting predominantly with the opioid μ receptor and exerting its principal pharmacological effect on CNS. Its primary action of therapeutic value is analgesia andsedation. It is extensively used for anaesthetic and analgesic most often in operating room and ICU [9].

The study was aimed to compare the effect of dexmedetomidine Vs fentanyl on haemodynamic response to tracheal intubation, following pneumoperitoneum and intraoperative period in patients undergoing laparoscopic surgery.

Materials and Methods

After obtaining approval from Hospital Ethical Committee (Ref No PPDYPU/164/2013) and informed consent from all patients, a prospective randomized, double blinded study was conducted on sixty patients admitted posted for different laparoscopic surgeries under general anaesthesia at Dr DY Patil Medical College and Hospital, Navi Mumbai, Maharashtra, India from January 2013 to January 2014.

Inclusion criteria were patient belonging to ASA Grade I and II, aged between 18-60 years, and of either sex. Exclusion criteria were pregnant and lactating women, patient with acute and chronic renal failure, compromised cardiovascular function, severe deranged liver function, patients with ASA Grade III and IV, haemodynamically compromised patients, emergency cases, patients with uncontrolled systemic disease, patients on α blocker and patients with HR <55/min.

Sixty patients were randomly allocated into two groups of 30 each to receive either dexmedetomidine (Group-D) or fentanyl (Group-F) using sequentially numbered envelopes. Sample size required was thirty in each group, determined based on previous study results on outcome, with a power of 0.9 and type 1 error 0.05 [10,11]. Patients were examined one day before scheduled surgery. Informed consent along with proper preoperative evaluation and relevant investigation as per case record form was done. No hypnotic medication was given on night before surgery. In operation theatre, preoperative base line parameters like HR, ECG, RR, SpO2, noninvasive SBP, DBP, MAP were recorded.

The study drugs were then prepared as follows.

About 2 ml (200 μg) of study drug dexmedetomidine was diluted in 48ml of normal saline to make 50 ml (concentration 4 μg/ml.). About 4 ml (200 μg) of study drug fentanyl was diluted in 46 ml normal saline to make 50 ml (conc. 4 μg/ml.)

Intra Venous access was secured with a 20 G cannula and infusion of Ringer’s lactate was started. The prepared drug dexmedetomidine or fentanyl was given as follows:

Group-D (N=30): IV dexmedetomidine 0.5 μg/kg was given as loading dose over 10 minutes prior to induction.

Group-F (N=30): IV fentanyl 0.5 μg/kg was given as a loading dose over 10 minutes prior to induction.

Ten minutes after infusion of drug dexmedetomidine or fentanyl, the parameters ECG, HR, RR, SBP, DBP, MAP and SpO2 were recorded.

Sedation was evaluated after the infusion of study drug, dexmedetomidine or fentanyl according to modified Ramsay sedation score [11,12].

The patient was pre-oxygenated with 100% oxygen for three minutes. Following this, inj. Glycopyrolate 0.2 mg IV (as and when required when HR<55/min), inj. ondansetron 4 mg I.V, inj. Tramadol 2 mg/kg I.V were given before induction.

Anaesthesia was induced with Inj Thiopentone 4-5 mg/kg I.V till there was loss of eye-lash reflex. Neuromuscular blockade was achieved with inj atracurium 0.75 mg/kg I.V. The parameters ECG, HR, RR, SBP, DBP, MAP and SpO2 were recorded after injection of induction drugs.

The patient was ventilated for three minutes with 100% O2 and isoflurane 0.8%. This was followed by laryngoscopy and tracheal intubation. Once tube position was confirmed, positive pressure ventilation was started with tidal volume 8 ml-10 ml/kg and respiratory rate 12-14/minute. The same parameters along with EtCo2 were again recorded immediately after tracheal intubation and five minutes after tracheal intubation. Depending upon the vital parameters, pulse and BP, maintenance infusion rate of dexmedetomidine or fentanyl was increased in a stepwise manner from 0.2-0.7 μg/kg/hour till the end of surgery.

Closed circuit breathing system with soda lime was used. Anaesthesia was maintained with isoflurane 0.8%-10% and O2, Nitrous oxide (40:60) along with atracurium 0.25-0.4 mg/kg for maintenance of blockade. Intraoperative sedation was augmented as and when required with Inj. propofol IV.

Intraoperatively the parameters like ECG, HR, SBP, DBP, MAP, SpO2, and EtCO2 were continuously recorded.

The above parameters were then recorded at predetermined time intervals as follows: T0 (prior to infusion of study drug), T1 (10 minutes after the study drug), T2 (after Inj. of induction drug), T3 (After intubation), T4 (five minutes after intubation), T5 (after pneumoperitoneum), T6 (five minutes after pneumoperitoneum), T7 (10 minutes after pneumoperitoneum), T8 (15 minutes after pneumoperitoneum), T9 (30 minutes after pneumoperitoneum), T10 (45 minutes after pneumoperitoneum), T11 (60 minutes after pneumoperitoneum), T12 (five minutes after release of pneumoperitoneum).

Adverse effects like bradycardia, tachycardia, hypotension, hypertension, nausea, vomiting, respiratory depression, if any, noted during operative procedure, were treated as follows:

Bradycardia - (HR<55/min): Inj. Glycopyrolate 0.2 mg I.V

Tachycardia – (HR >30% above baseline value): Inj. Propofol 20 mg I.V in titrated dose

Hypotension – (SBP<60 mmHg) Inj. Ephedrine 6 mg I.V in titrated dose

Hypertension – (SBP> 140 mmHg): Inj. Propofol 20 mg I.V in titrated dose and increasing concentration of isoflurane up to 1.2%.

First dose of rescue analgesia in postoperative period with IV paracetamol and subsequent amount of rescue analgesia with IV paracetamol administered in recovery room were recorded depending on Visual Analogue Scale (VAS) pain score.

At completion of surgery port site was infiltrated with 0.5% bupivacaine 2-3 ml per port for postoperative analgesia. Fluid deficit, maintenance and loss were replaced with an infusion of lactated Ringer solution.

Infusion of drug (dexmedetomidine or fentanyl) was stopped and isoflurane was discontinued 10 minutes before reversal. Residual paralysis was reversed with Inj. Neostigmine 0.05 mg/kg IV, and Inj. Glycopyrolate 8 μg/kg IV. Patient was then extubated after thorough oral suction.

Parameters were again recorded at five minute (T13) and 10 minute (T14) after extubation.

Statistical Analysis

The results were expressed as number of occurrences, percentage (%) and mean±S.D. Demographic characteristics, preoperative vitals were compared using Student’s t-test and nominal data were compared with Chi-square test. Repeated measures of analysis of variance (RMANOVA) was used to compare continuous variables. Statistical analysis was performed using Graph Pad Instat software package. A p-value of <0.05 was considered statistically significant.

Results

Demographic profile including age, sex, weight, ASA physical status, duration of anaesthesia and type of operation proposed in both the groups have been presented in [Table/Fig-1,2].

Demographic profile.

ParametersGroup-DGroup-Fp-value
Age (in years)37.9±13.16834.7±11.470.748
Sex (M/F)10:2011:190.787
Weight (in Kg)55.93±10.79354.13±10.9570.124
ASA status (1/2)24/625/50.739
Duration of surgery (minutes)96.77±31.04184.633±17.7930.053

Comparison using Chi square test


Operation proposed.

Operation proposedGroup-DGroup-Fp-value
Lap cholecystectomy11 (36.66%)10 (33.33%)0.231
Lap appendicectomy9 (30%)8 (26.66%)
LAVH5 (16.66%)4 (13.32%)
Lap myomectomy2 (6.66%)2 (6.66%)
Diagnostic laparoscopy3 (19%)6 (20%)

Comparison by Chi-square test

[Lap-Laparoscopic, LAVH- Laparoscopic assisted vaginal hysterectomy]


The preoperative baseline haemodynamic parameters like mean HR, SBP, DBP, SPO2 in Group D and in Group F were also comparable between two groups [Table/Fig-3,4,5 and 6].

Perioperative means of heart rate in Rates/minutes.

TimeTGroup DGroup Fp-value
Mean±S.DMean±S.D
Prior to infusion of drugsT084.9±2.89381.03±7.6720.240
10 minutes after the drugT173.6±3.18573.4±8.8890.951
After inj. of induction drugT280.1±3.12180.1±8.6761.000
After intubationT388.47±14.282100.37±13.2940.001
5 minutes after intubationT480.53±11.8995.8±10.9020.001
After pneumoperitoneumT581.3±13.67990.1±13.8970.012
5 minutes after pneumoperitoneumT679.03 ±12.26387.9±10.4170.008
10 minutes after pneumoperitoneumT779.4±12.75787.47±9.130.013
15 minutes after pneumoperitoneumT879.33±13.32291.87±10.4440.002
30 minutes after pneumoperitoneumT985.73±13.85491.37±10.2130.072
45 minutes after pneumoperitoneumT1082.47±12.36290.73±9.5660.010
60 minutes after pneumoperitoneumT1182±10.91792.23±10.0370.001
5 minutes after release of pneumoperitoneumT1277.67±10.69189.77±9.7970.002
5 minutes after post extubationT1382.63±10.58194.43±10.8710.001
10 minutes after extubationT1483.27±9.67794.33±9.1810.003

Comparison using Student t-test


Perioperative systolic blood pressure in mmHg.

TimeTGroup-DGroup-Fp-value
Mean±S.DMean±S.D
Prior to infusion of drugsT0125.67±11.751119.43±22.2690.173
10 minutes after the drugT1114.73±13.630123.20±10.9780.010
After inj. of induction drugT2108.23±13.650121.80±11.2630.001
After intubationT3125.13±13.903142.57±22.1250.001
5 minutes after intubationT4113.90±12.783126.90±9.1510.001
After pneumoperitoneumT5114.23±12.204124.63±15.1870.006
5 minutes after pneumoperitoneumT6116.87±11.038128.40±14.5170.004
10 minutes after pneumoperitoneumT7120.20±9.939131.43±12.5140.001
15 minutes after pneumoperitoneumT8119.43±10.740124.87±25.3180.283
30 minutes after pneumoperitoneumT9123.53±8.253128.30±14.6970.145
45 minutes after pneumoperitoneumT10120.37±8.231129.57±14.2460.005
60 minutes after pneumoperitoneumT11121.60±9.050126.27±15.3280.177
5 minutes after release of pneumoperitoneumT12115.30 ± 10.723125.73 ± 14.0560.001
5 minutes after post extubationT13121.47±10.938129.47±14.7340.030
10 minutes after extubationT14123.93±10.255126.03±12.8450.541

Comparison using Student t test


Perioperative diastolic blood pressure in mmHg.

TimeTGroup-DGroup-Fp-value
Mean±S.DMean±S.D
Prior to infusion of drugsT078.33±7.60877.10±8.8290.573
10 minutes after the drugT174.63±8.23174.00±7.6340.774
After inj. of induction drugT270.43±11.06979.13±9.3210.002
After intubationT381.07±10.01788.23±13.9030.027
5 minutes after intubationT473.73±9.27078.80±7.5810.031
After pneumoperitoneumT574.67±12.27980.23±11.9210.066
5 minutes after pneumoperitoneumT676.90±8.68782.57±13.3330.085
10 minutes after pneumoperitoneumT776.87±9.97183.57±11.8780.015
15 minutes after pneumoperitoneumT876.67±8.72380.40±13.7130.208
30 minutes after pneumoperitoneumT976.80 ± 7.86379.67±11.3760.217
45 minutes after pneumoperitoneumT1074.27±4.16879.17±11.8150.037
60 minutes after pneumoperitoneumT1176.60±4.98077.43±11.1810.698
5 minutes after release of pneumoperitoneumT1274.67±5.49880.10±9.6860.005
5 minutes after post extubationT1378.17±10.55780.97±10.4600.340
10 minutes after extubationT1478.13±9.38779.50±8.9120.581

Comparison using Student t-test


Perioperative mean arterial pressure in mmHg.

TimeTGroup-DGroup-Fp-value
Mean±S.DMean±S.D
Prior to infusion of drugsT092.23±8.45191.17±7.4610.546
10 minutes after the drugT182.47±7.99089.40±8.1830.002
After inj. of induction drugT281.70±10.81292.43±9.4380.001
After intubationT393.80±10.233105.43±15.8430.002
5 minutes after intubationT485.50±9.66694.13±7.2430.001
After pneumoperitoneumT585.97±11.40693.80±12.7430.011
5 minutes after pneumoperitoneumT689.10±8.34796.90±12.6530.015
10 minutes after pneumoperitoneumT790.17±8.06998.03±11.0280.001
15 minutes after pneumoperitoneumT890.33±7.86795.27±12.2280.075
30 minutes after pneumoperitoneumT991.50±7.32894.47±10.5100.179
45 minutes after pneumoperitoneumT1089.00±4.38694.70±11.0930.015
60 minutes after pneumoperitoneumT1190.97±5.38592.87±10.8330.409
5 minutes after release of pneumoperitoneumT1288.03±6.28394.37 ± 9.7570.002
5 minutes after post extubationT1391.93±9.80896.07±9.7450.137
10 minutes after extubationT1491.97±8.83895.23±9.1870.185

Comparison using Student t-test


Ten minutes after the infusion of test drug (T1), when sedation score is compared, 12 (40%) in Group D patients were calm and cooperative, 18 (60%) were sedated but responded to commands. In Group F, 20 (66.6%) patients were calm and cooperative, 10(33.3%) were sedated but responded to commands. Though sedation was significantly higher in dexmedetomidine Group (Group D) than fentanyl (Group F) (p=0.001), most of the patients could be easily aroused and none were deeply sedated.

There was 13% fall in HR, 9% fall in SBP, 5% fall in DBP and 10.8% fall in MAP below baseline in Group D as compared to 10% fall in HR, no fall in SBP, 4% fall in DBP and 2% decrease in MAP in Group F, 10 minutes after infusion of test drug [Table/Fig-3,4,5 and 6].

After intubation (T3) there was 5% rise in HR, 9% rise in SBP, 3% rise in DBP and 2% rise in MAP from baseline value in Group D as compared to 18% rise in HR, 19% rise in SBP, 15% rise in DBP and 15% rise in MAP in Group F with p<0.05 which is significant [Table/Fig-3,4,5 and 6].

After pneumoperitoneum (T5) HR decreased by 3.5%, SBP and DBP fell by 8.8% and 4.2% respectively in Group D (dexmedetomidine) as compared to 3.5% rise in HR, 4.2% rise in SBP and 3.8% rise in DBP in fentanyl Group [Table/Fig-3,4,5 and 6].

Throughout intraoperative period of pneumoperitoneum Group D showed significant fall in HR, SBP, DBP, MAP from baseline value at all points of time intervals whereas it remains above baseline value in Group F.

At five minutes and 10 minutes after extubation the HR, SBP, DBP showed fall from baseline in Group D whereas, it remains above baseline in Group F, though not statistically significant.

Intraoperative hypertension was found in three patients (10%) in Group D whereas, it was 19 (63.3%) in Group F. Bradycardia was observed in one patient (3.3%) in Group D whereas, tachycardia was observed in four patients (10%) in Group F during intubation and in perioperative period.

Nausea and vomiting were found in two patients (6%) in Group D and three patients (10%) in Group F in postoperative period.

Postoperatively the mean duration of adequate analgesia was 81.233±16.515 minutes in Group D whereas it was 41.87±10.180 minutes in Group F, (p-value 0.001) which is statistically significant.

None of our patients in both groups have any respiratory depression. None developed any ECG abnormality. There was no significant difference in pre and intraoperative SpO2 and EtCO2 values [Table/Fig-7].

Comparision of EtCO2 in both groups.

TimeTGroup-DGroup-Fp-value
Mean±S.DMean±S.D
After intubationT332±4.232.1±4.80.13
5 minutes after intubationT433.9±4.832.4±5.30.06
After pneumoT532.4±5.934.4±6.40.19
5 minutes after pneumoT633.6±4.134.5±5.50.15
10 minutes after pneumoT734±6.233.5±4.90.82
15 minutes after pneumoT834.6±4.533.2±5.10.66
30 minutes after pneumoT931.9±5.131.6±5.40.48
45 minutes after pneumoT1031.2±3.131.7±4.60.15
60 minutes after pneumoT1133.5±4.332.5±4.60.40
5 minutes after release of pneumoT1232.8±5.032.1±6.60.23

Comparison using Student t-test


Discussion

Pneumoperitoneum causes increase in systemic vascular resistance, mean arterial pressure, cardiac filling pressure and decrease in cardiac index. The CO2 insufflation results in its peritoneal absorption producing hypercarbia, which stimulates sympathetic nervous system and thus increases BP, HR and the risk of arrhythmia. Hypercapnia may cause a decrease in myocardial contractility and lowers arrhythmia threshold [13-15].

Only limited studies [16-18] have been done comparing the effect of IV dexmedetomidine versus IV fentanyl as premedicant on perioperative haemodynamic agent in laparoscopic surgery. So we conducted this study to compare the effects of dexmedetomidine and fentanyl on haemodynamic response to tracheal intubation, following pneumoperitoneum and intraoperative period in patient undergoing laparoscopic surgery.

Dexmedetomidine is increasingly being used as a sedative for Monitored Anaesthesia Care (MAC) because of its cooperative sedation, anxiolysis and lack of respiratory depression effect. In our study, we found that both dexmedetomidine and fentanyl produce sedation but patients who received dexmedetomidine are better sedated with higher Ramsay sedation score. Our findings are in agreement with Keniya VM et al., who reported that more patients in the group injected with 1 μg/kg of dexmedetomidine received treatment for bradycardia than patients in the fentanyl group [10]. Patel CR et al., also found that postoperatively dexmedetomidine (1 μg/kg) shows significant sedation at two hours than fentanyl (2 μg/kg) [11].

We used dexmedetomidine in the same dose as Techanivate A et al., [16]. The side effects of dexmedetomidine are hypotension, bradycardia, nausea, vomiting, hypoxia, acidosis and atrial fibrillation. These are dose dependent and an increase in dose (1 μg-2 μg/kg) is associated with more side effects [19] Tufanogullari B et al., also used dexmedetomidine at dose of 0.2–0.8 μg/kg/hour in bariatric surgery to minimize adverse cardiovascular side effects [20].

We have used fentanyl in a dose of 0.5 μg/kg as bolus infusion prior to induction followed by 0.2-0.7 μg/kg/hour infusion till completion of operation. Similar dose was used by other authors like Techanivate A et al., (0.5 μg/kg of bolus infusion of fentanyl) in gynaecologic diagnostic laparoscopy and by Feld J et al., (0.5 μg/kg of bolus infusion of fentanyl) to facilitate anaesthesia and to attenuate autonomic activity during laparoscopic gastric banding [16,17]. 0.25 μg/kg nearly of fentanyl as bolus infusion was also used by Uysal HY et al., to attenuate haemodynamic response to tracheal intubation in hypertensive patients [21].

In our study, demographic data showed that Group D (dexmedetomidine) and Group F (fentanyl) were comparable in terms of number of patients, age, sex, weight, ASA status, types and duration of laparoscopic surgeries.

Our observation of significantly less increase in HR in dexmedetomidine group in comparision with fentanyl group after intubation, after pneumoperitoneum, in intraoperative period and after extubation is in accordance with that of other authors [17]. This is because dexmeditomidine effectively blunts sympathoadrenal response to intubation and has good sympatholytic activity. Suparto et al., concluded that both dexmedetomidine at 1 μg/Kg and fentanyl at 1 μg/Kg given intravenously as single bolus dose prior to anaesthesia induction produced lowering of blood pressures and cardiac rates, with significantly lower mean heart rates with dexmedetomidine i.e., 23% decrease in dexmedetomidine group vs 6% decrease in fentanyl group [18]. They also observed that patients receiving dexmedetomidine exhibit less increase in HR from induction level, after laryngoscopy and intubation.

In the present study, there is less fluctuation in SBP and DBP and MAP in dexmedetomidine group in comparision to fentanyl with p-value <0.05 after intubation, after pneumoperitoneum and after extubation. This implies that dexmedetomidine had attenuated stress response at these time points. Similar findings were observed by Patel CR et al., who found lesser increase in SBP (6% vs 23%), DBP (7% Vs 20%) after intubation with dexmedetomidine 1 μg/kg as compared to fentanyl 2 μg/kg when given as loading dose prior to induction [11].

Intraoperatively, an average of 8% fall in SBP and 8.16% fall in DBP in dexmedetomidine group as compared to 3.65% rise in SBP and 3.3% rise in DBP in fentanyl group was also observed. Our observations are consistent with that of Gupta K et al., and Shareef SM et al., who observed that both dexmedetomidine (1 μg/kg) and fentanyl (2 μg/kg), when used as premedicant before induction attenuated the haemodynamic response to pneumoperitoneum during laparoscopic surgeries [22,23]. Dexmedetomidine group showed less increase in SBP, DBP and more stabilization of intraoperative MAP and HR as compared to fentanyl group.

We found that duration of postoperative analgesia was significantly higher in dexmedetomidine group compared to fentanyl group (p=0.001). There was more delay in need for first dose of rescue analgesia in dexmedetomidine group than fentanyl group. Our findings were consistent with that of Turgut N et al., who concluded that fentanyl group require higher dose of postoperative analgesic than dexmedetomidine group [24]. The fentanyl group also required analgesia earlier than dexmedetomidine group (34.8+/-1.35 minutes vs 60.4+/-1.04 minutes).

Limitation

We have done a small study of 60 patients and we did not measure cardiac output, systemic vascular resistance and serum catecholamine levels. Also, the minimal suppression of haemodynamic response observed in the fentanyl group observed in our study may be due to the low dose used. Ko HS et al., reported 2 μg/kg of fentanyl was an optimal dose to attenuate haemodynamic response to laryngoscopy and tracheal intubation. In spite of the above limitations some conclusions could be made [25].

Conclusion

To conclude, dexmedetomidine when compared to fentanyl causes greater attenuation of stress response to tracheal intubation, following pneumoperitoneum and in perioperative period resulting in greater reduction of HR, SBP, DBP, MAP than that of fentanyl, thus causing better haemodynamic stability in patients undergoing elective laparoscopic surgery. Dexmedetomidine also provides better sedation while maintaining patients arousability and has more analgesic sparing effect and causes lesser requirement of anaesthetic agent in perioperative period without much adverse effect.

Hence, intravenous premedication with dexmedetomidine in dose of 0.5 μg/kg as loading dose over 10 minutes prior to induction in laparoscopic surgeries followed by 0.2-0.7 μg/kg infusion till surgery is over, may be recommended for better haemodynamic stability during perioperative period despite high cost.

Comparison using Chi square testComparison by Chi-square test[Lap-Laparoscopic, LAVH- Laparoscopic assisted vaginal hysterectomy]Comparison using Student t-testComparison using Student t testComparison using Student t-testComparison using Student t-testComparison using Student t-test

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