Sialochemical Profile in Depressive Individuals under Antidepressant Therapy: An Observational StudyCorrespondence Address :
Dr. Umamaheswari Giri,
Postgraduate Student, Department of Oral Pathology, Indira Gandhi Institute of Dental Sciences,
Sri Balaji Vidyapeeth University, Pillaiyarkuppam-607402, Puducherry, India.
Introduction: Depression is a mental disorder that is pervasive and affects people all around the World. In India about one in five people are affected by depressive disorders. Autonomic Nervous System (ANS) affected by depressive disorder can affect salivary composition, since salivary secretion is controlled by the sympathetic and parasympathetic innervations. Likewise, antidepressants are the drugs which can elevate mood in depressive disorders, and also have potential to alter salivary secretion rate and their composition. Alteration in salivary composition can affects oral health and makes them vulnerable for oral infection.
Aim: To study the sialochemical alteration in depressive individuals and to compare the effect of antidepressant therapy (selective serotonin reuptake inhibitors-two month course) on the same patients.
Materials and Methods: A total of 80 subjects-Group I (40 controls), Group II (40-depressive individuals) and Group III (Group II depressive individuals after two months course of antidepressant therapy). Depression level was assessed with Hospital Anxiety and Depression Scale (HADS). Whole unstimulated saliva was collected and subjected to sialochemical analysis (sodium, potassium, chloride, total protein, urea, salivary amylase, calcium, pH). The parameters were statistically analysed using Unpaired t-test to compare Group I and II and Paired t-test to compare Group II and III.
Results: It showed statistically significant alteration in parameters such as total protein, salivary a-amylase, chloride, and calcium. While comparing Group II and Group III it showed significant reduction in total protein and calcium levels in Group III individuals.
Conclusion: The post-treatment sialochemical analysis showed that depressive individuals got stabilised and reverted back to the normal baseline value of the healthy individuals which proves that Selective Serotonin Reuptake Inhibitors (SSRI) does not produce profound sialochemical alteration.
Depressive disorder, Neurophysiology, Norepinephrine sialochemistry
Umamaheswari Giri, Vezhavendhan Nagaraj, Avudaiappan Sankaran, Ramesh R, Suganya Rajaram, Sivaramakrishnan Muthanandam, et al.. SIALOCHEMICAL PROFILE IN DEPRESSIVE INDIVIDUALS UNDER ANTIDEPRESSANT THERAPY: AN OBSERVATIONAL STUDY. Journal of Clinical and Diagnostic Research [serial online] 2018 May [cited: 2018 May 21 ]; 12:VC06-VC09. Available from
Date of Submission: Apr 10, 2017
Date of Peer Review: Jul 10, 2017
Date of Acceptance: Nov 11, 2017
Date of Publishing: May 01, 2018
FINANCIAL OR OTHER COMPETING INTERESTS: None.
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