Efficacy and Safety of Different Prophylactic Doses of Phenylephrine for Prevention of Spinal Anaesthesia induced Hypotension in Cesarean Section-A Randomised Controlled TrialCorrespondence Address :
Dr. Madhumita Ray,
Assistant Professor, Department of Anaesthesiology, College of Medicine and JNM Hospital, WBUHS, Kalyani,
Nadia-741235, West Bengal, India.
E-mail: firstname.lastname@example.org, email@example.com
Introduction: Spinal anaesthesia is a standard technique for elective caesarean section. But, hypotension is the main complication, which adversely affects both mother and foetus.
Aim: To evaluate the efficacy and safety of different prophylactic doses of phenylephrine for prevention of spinal anaesthesia induced hypotension.
Materials and Methods: This prospective, randomised, double blinded controlled study was conducted on 104 pregnant mothers who fulfilled the subject selection criteria. Patients were randomly allocated into four groups: Group A received 2 mL of 0.9% saline solution Intramuscularly (IM), Group B, Group C and Group D received 1 mg, 2 mg, and 3 mg of phenylephrine (made in 2 mL of 0.9% saline) IM, respectively. Hyperbaric bupivacaine 0.5%, 2.5 mL was administered intrathecally to all subjects. Haemodynamic parameters: Systolic Blood Pressure (SBP), Mean arterial Blood Pressure (MBP), Diastolic Blood Pressure (DBP), Heart Rate (HR) were recorded throughout the surgery at three minutes interval and 10 minutes interval for one hour after surgery (study period). Adverse events were also noted throughout the study period.
Fisher’s exact test, Kruskall-Wallis test, Friedman’s ANOVA were done for statistical analysis.
Results: Subjects of Group D had least episode of hypotension (2 times) than Group A (13 times). Subjects of Group D required least amount of rescue medication (73.91±22.85 mcg) than Group A (435±39.25 mcg) that was statistically significant (p<0.001). Incidence of nausea and vomiting were least in subjects of Group D (7.69%) than Group A (66.67%) which was statistically significant (p<0.001).
Conclusion: Prophylactic 3 mg IM phenylephrine is effective to lower the incidence of spinal anaesthesia induced hypotension in elective caesarean section with minimal tolerable adverse effects.
Anaesthetic techniques, Double blinded study, Phenylephrine
Chanchal Kumar Dalai, Soumita Roy, Madhumita Ray, Abhishek Ghosh. EFFICACY AND SAFETY OF DIFFERENT PROPHYLACTIC DOSES OF PHENYLEPHRINE FOR PREVENTION OF SPINAL ANAESTHESIA INDUCED HYPOTENSION IN CESAREAN SECTION-A RANDOMISED CONTROLLED TRIAL. Journal of Clinical and Diagnostic Research [serial online] 2018 May [cited: 2018 Aug 20 ]; 12:UC01-UC06. Available from
Date of Submission: May 23, 2017
Date of Peer Review: Sep 19, 2017
Date of Acceptance: Dec 14, 2017
Date of Publishing: May 01, 2018
FINANCIAL OR OTHER COMPETING INTERESTS: None.
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