Refractory Thrombotic Thrombocytopenic Purpura: A Case ReportCorrespondence Address :
Dr. Prabu Pandurangan,
Greams Road, Apollo Hospital, Chennai-600001, Tamil Nadu, India.
Thrombotic thrombocytopenic purpura is a thrombotic microangiopathy. Clinical manifestations occur due to decreased perfusion to the internal organs. Usually it responds to pulse steroids and plasma exchange. Various therapies are available for refractory cases which respond to N-Acetyl cysteine, cyclosporin, rituximab, bortezomib and caplacizumab. We report a case of refractory Thrombotic Thrombocytopenic Purpura (TTP) in a 29-years-old female showed improvement with the use of rituximab (anti-CD 20 monoclonal antibody), who presented with history of fever and one episode of seizure.
N-Acetyl cysteine, Rituximab, Splenectomy
Mohammed Shafi Abdulsalam, Venkateshwaran Radhakrishnan, Prabu Pandurangan. REFRACTORY THROMBOTIC THROMBOCYTOPENIC PURPURA: A CASE REPORT. Journal of Clinical and Diagnostic Research [serial online] 2018 March [cited: 2018 Jun 20 ]; 12:OD01-OD02. Available from
Date of Submission: Mar 18, 2017
Date of Peer Review: May 17, 2017
Date of Acceptance: Jan 16, 2018
Date of Publishing: Mar 01, 2018
FINANCIAL OR OTHER COMPETING INTERESTS: None.
- Emerging Sources Citation Index (Web of Science, thomsonreuters)
- Index Copernicus ICV 2016: 132.37
- Academic Search Complete Database
- Directory of Open Access Journals (DOAJ)
- Embase & EMbiology
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Popline (reproductive health literature)