Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2018 | Month : March | Volume : 12 | Issue : 3 | Page : UC05 - UC08

Comparative Analysis of Dexmedetomidine and Propofol Based Sedation Regimens on Anaesthetic Requirements in Cardiac Surgery with On-pump Cardiopulmonary Bypass

Sheikh Ahmad Tufail, Nadeem Ahmad, Nihida Akhter

1. Senior Resident, Department of Anaesthesiology and Intensive Care, Shri Maharaja Hari Singh Hospital, Srinagar, Jammu and Kashmir, India. 2. Senior Resident, Department of Gastroenterology, Sheri Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India. 3. Senior Resident, Department of Gynaecology and Obstetrics, Lala Ded Hospital, Srinagar, Jammu and Kashmir, India.

Correspondence Address :
Dr. Sheikh Ahmad Tufail,
Senior Resident, Department of Anaesthesiology and Intensive Care, Shri Maharaja Hari Singh Hospital,
Srinagar-190001, Jammu and Kashmir, India.
E-mail: tufail.ahmad99@gmail.com

Abstract

Introduction: Dexmedetomidine is a selective a2-agonist that has been successfully used as an anaesthetic adjuvant in cardiac surgery.

Aim: To evaluate the effect of dexmedetomidine on intraoperative requirements of isoflurane and opioids for maintenance of anaesthesia during On-pump cardiac surgery and compare the anaesthesia sparing effect with that of propofol.

Materials and Methods: This was a randomised, double blind observational study. Morphine consumption and minimum alveolar concentration of isoflurane was compared among 60 patients planned for elective open heart surgeries who were randomised to receive either dexmedetomidine (1 µg/kg bolus over 10 minutes followed by infusion of 0.2 to 0.6 µg/kg/hour) or propofol (0.25-1 mg/kg/hour) throughout the intraoperative period till skin closure. The drug infusions were titrated to target Bispectral Index (BIS) score of 40-60. BIS scores and minimum alveolar concentration of isoflurane were recorded at predetermined intervals during surgery. Total dose of morphine used was also recorded. Statistical analysis was carried out using analysis of variance, Chi-square test, Student’s t-test and Mann–Whitney U test.

Results: BIS scores were significantly lower in dexmedetomidine group (p<0.05). Total dose of morphine and minimum alveolar concentration of isoflurane were significantly lower in dexmedetomidine group (p<0.05).

Conclusion: From the results we concluded that intraoperatively administered dexmedetomidine during On-pump cardiac surgery has specific analgesic properties and decreases intraoperative anaesthetic requirement. Thus, dexmedetomidine has significant opioid and anaesthetic sparing property.

Keywords

Adjuvant, Anaesthesia, Intensive care, Minimum alveolar concentration, Morphine

How to cite this article :

Sheikh Ahmad Tufail, Nadeem Ahmad, Nihida Akhter. COMPARATIVE ANALYSIS OF DEXMEDETOMIDINE AND PROPOFOL BASED SEDATION REGIMENS ON ANAESTHETIC REQUIREMENTS IN CARDIAC SURGERY WITH ON-PUMP CARDIOPULMONARY BYPASS. Journal of Clinical and Diagnostic Research [serial online] 2018 March [cited: 2018 Jun 20 ]; 12:UC05-UC08. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2018&month=March&volume=12&issue=3&page=UC05-UC08&id=11251

DOI and Others

DOI: 10.7860/JCDR/2018/34674.11251

Date of Submission: Nov 5, 2017
Date of Peer Review: Jan 10, 2018
Date of Acceptance: Jan 22, 2018
Date of Publishing: Mar 01, 2018

FINANCIAL OR OTHER COMPETING INTERESTS: None.

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