Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2018 | Month : June | Volume : 12 | Issue : 6 | Page : DC56 - DC60

Cut-off Levels of CRP to Predict Outcomes in Patients with Influenza Infection

Omer Karasahin, Hasan Selçuk Özger, Rezan Harman, Sibel Iba Yilmaz

1. Consultant, Department of Infectious Diseases, Erzurum Regional Education and Research Hospital, Erzurum, Turkey. 2. Consultant, Department of Infectious Diseases, Dr. Ersin Arslan Regional Education and Research Hospital, Gaziantep, Turkey. 3. Consultant, Department of Infectious Diseases, Gaziantep SANKO Hospital, Gaziantep, Turkey. 4. Consultant, Department of Infectious Diseases, Erzurum Regional Education and Research Hospital, Erzurum, Turkey.

Correspondence Address :
Dr. Omer Karasahin,
Atatürk Mahallesi Çat Yolu Caddesi, 25040 Yakutiye/Erzurum, Turkey.
E-mail: mrkrhsn@hotmail.com

Abstract

Introduction: Seasonal flu is an acute viral infection caused by an influenza virus. People with weakened or suppressed immune system and people with existing chronic disorders are at a greater risk of serious complications after exposure to influenza virus infection. Therefore, determining prognostic markers that are practical, accessible and assessable within the first 24 hours of admission, is of great importance.

Aim: To determine the cut-off levels for several bio-chemical markers to predict mortality and determine which patient would require ICU admission in adults with Influenza A infection.

Materials and Methods: All patients (155) included in the study were above the age of 18 years and diagnosed with Influenza A from December 2015 to March 2016. ROC analysis, Cox regression model and Kaplan-Meier analysis were used to determine the prognostic predictions of the biomarkers, C-Reactive Protein (CRP), Creatine Kinase (CK) and risk factors.

Results: Serum CRP and CK levels were significantly high in patients who required ICU support or died. The highest sensitivity and specificity cut-off value for mortality and intensive care unit needs was 76.5 mg/L for CRP. The highest sensitivity and specificity cut-off value for mortality prediction of CK was 234 U/L, and that for intensive care unit needs was 302 U/L. With each 1 mg/L increase in serum CRP values, the risk of mortality increased by 1.007 times (95% CI 1.001-1.013; p=0.017). The mean life span of patients with serum CRP levels above 76.5 mg/L was shortened.

Conclusion: The cut-off value of CRP for ICU admission and mortality was indicated as 76.5 mg/L. The frequency of development of mortality in cases below this limit value was determined as <1% and survival times were found significantly longer.

Keywords

C-reactive protein, Creatine kinase, Intensive care unit

How to cite this article :

Omer Karasahin, Hasan Selçuk Özger, Rezan Harman, Sibel Iba Yilmaz. CUT-OFF LEVELS OF CRP TO PREDICT OUTCOMES IN PATIENTS WITH INFLUENZA INFECTION. Journal of Clinical and Diagnostic Research [serial online] 2018 June [cited: 2018 Jun 24 ]; 12:DC56-DC60. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2018&month=June&volume=12&issue=6&page=DC56-DC60&id=11695

DOI and Others

DOI: 10.7860/JCDR/2018/35263.11695

Date of Submission: Dec 20, 2017
Date of Peer Review: Feb 02, 2018
Date of Acceptance: Apr 20, 2018
Date of Publishing: Jun 01, 2018

FINANCIAL OR OTHER COMPETING INTERESTS: NONE.

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