Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2018 | Month : June | Volume : 12 | Issue : 6 | Page : BC25 - BC28

Correlation of Serum Nitric Oxide with Haematological and Biochemical Parameters in Acute Ischaemic Stroke Patients

Priti Chaturvedi, Vinit Mehrotra, Yogesh Saxena, Soumen Manna

1. Assistant Professor, Department of Biochemistry, Swami Rama Himalayan University, Dehradun, Uttarakhand, India. 2. Professor, Department of Biochemistry, Swami Rama Himalayan University, Dehradun, Uttarakhand, India. 3. Associate Professor, Department of Physiology, Swami Rama Himalayan University, Dehradun, Uttarakhand, India. 4. Assistant Professor, Department of Physiology, Swami Rama Himalayan University, Dehradun, Uttarakhand, India.

Correspondence Address :
Dr. Soumen Manna,
Assistant Professor, Department of Physiology, Swami Rama Himalayan University, Jolly Grant, Dehradun-248016, Uttarakhand, India.
E-mail: drsoumen.manna@gmail.com

Abstract

Introduction: Nitric oxide (NO), different haematological and biochemical parameters, play an important role in the pathogenesis of Acute Ischaemic Stroke (AIS) (<24 hour).

Aim: To establish a correlation between NO with haematological and biochemical parameters in AIS patients.

Materials and Methods: A hospital based, cross-sectional study was done in 50 patients of AIS and 25 healthy controls. Serum NO level was measured by ELISA. Complete lipid profile, Random Blood Sugar (RBS), serum Blood Urea Nitrogen (BUN), creatinine and haemogram were assessed by automated devices. Pearson’s correlation coefficients were analysed to look for the relationship between NO with biochemical and haematological parameters. The p-value was considered significant if p<0.05.

Results: Statistically highly significant (p<0.001) elevation in mean serum NO levels were observed in cases (32.06 µmol/L) as compared to controls (24.41 µmol/L). NO was positively correlated with elevated levels of Triacylglycerol (TAG), T-Chol, Low Density Lipoprotein (LDL-C), VLDL-C, RBS, and negatively correlated with High Density Lipoprotein (HDL-C), BUN, serum creatinine, Total Leukocyte Count (TLC), ESR, but none of the correlation coefficient was found to be statistically significant.

Conclusion: Elevated NO and derangement of biochemical and haematological parameters may be linked to pathogenesis of AIS.

Keywords

Acute stroke, Erythrocyte sedimentation rate, Lipoprotein cholesterol, Total leukocyte count

How to cite this article :

Priti Chaturvedi, Vinit Mehrotra, Yogesh Saxena, Soumen Manna. CORRELATION OF SERUM NITRIC OXIDE WITH HAEMATOLOGICAL AND BIOCHEMICAL PARAMETERS IN ACUTE ISCHAEMIC STROKE PATIENTS. Journal of Clinical and Diagnostic Research [serial online] 2018 June [cited: 2018 Aug 16 ]; 12:BC25-BC28. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2018&month=June&volume=12&issue=6&page=BC25-BC28&id=11700

DOI and Others

DOI: 10.7860/JCDR/2018/32132.11700

Date of Submission: Sep 01, 2017
Date of Peer Review: Oct 17, 2017
Date of Acceptance: Mar 29, 2018
Date of Publishing: Jun 01, 2018

FINANCIAL OR OTHER COMPETING INTERESTS: NONE.

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