Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

Users Online : 23997

Original article / research
Year : 2018 | Month : June | Volume : 12 | Issue : 6 | Page : BC13 - BC16

Influence of Type 2 Diabetes on Serum Electrolytes and Renal Function Indices in Patients

Godwill Azeh Engwa, Friday Nweke Nwalo, Thom-Justus Chidera Atta ma, Micheal Chinweuba Abonyi, Emmanuela N. Akaniro-Ejim, Marian N. Unachukwu, Ambrose N. Njokunwogbu, Benjamin Ewa Ubi

1. Lecturer, Department of Chemical Sciences, Godfrey Okoye University, Enugu, Nigeria. 2. Associate Professor, Department of Biotechnology, Federal University Ndufu-Alike Ikwo (FUNAI), Ebonyi State, Nigeria. 3. Researcher, Department of Chemical Sciences, Godfrey Okoye University, Enugu, Nigeria. 4. Medical Doctor, Department of Internal Medicine, College of Medicine, Enugu State University Teaching Hospital (ESUTH), Enugu, Nigeria. 5. Lecturer, Department of Biotechnology, Godfrey Okoye University, Enugu, Nigeria. 6. Senoir Lecturer, Department of Microbiology, Godfrey Okoye University, Enugu, Nigeria. 7. Lecturer, Department of Chemical Sciences, Godfrey Okoye University, Enugu, Nigeria. 8. Professor, Department of Biotechnology, Ebonyi State University, Abakaliki, Ebonyi State, Nigeria.

Correspondence Address :
Dr. Godwill Azeh Engwa,
Lecturer, Department of Chemical Sciences, Godfrey Okoye University, P.M.B 01014, Thinkers Corner, Enugu, Nigeria.
E-mail: engwagodwill@gmail.com

Abstract

Introduction: Type 2 diabetes, a disease condition characterised by hyperglycaemia can damage the kidney, an organ which regulates water and electrolytes. Also, high blood sugar can increase plasma osmolarity thereby, drifting water movement from the intracellular to the extracellular spaces and alter the distribution of electrolytes in the body. However, little is known on the relationship between serum electrolytes, renal function and Type 2 Diabetes (T2D).

Aim: This study was aimed to assess the serum electrolyte level of diabetic patients in order to evaluate the relationship of these electrolytes with renal dysfunction indices as well as other diabetes risk factors in T2D patients.

Materials and Methods: A case-control study involving 72 T2D and 75 Non-Diabetic (ND) outpatients was conducted at Enugu State University Teaching Hospital (ESUTH) Enugu, Nigeria. The patientsí demographic and anthropometric data was obtained and the serum electrolytes; potassium (K+), sodium (Na+) and chloride (Cl-) ions along with creatinine and urea as renal function indices were measured.

Results: Serum K+ was significantly higher (p = 0.002) in T2D patients while Na+, Cl-, creatinine and urea were insignificantly higher in T2D patients compared to the ND patients. Serum K+ disorder were significantly greater (p<0.05) in T2D patients as 8.8% of T2D patients were hyperkalaemic compared to ND patients (2.7%). Creatinine level positively correlated with K+ (p = 0.004) while age, Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) correlated with serum electrolytes.

Conclusion: T2D was found to promote electrolyte imbalance particularly potassium ion derangement and may affect renal function. Risk factors of T2D such as old age and high blood pressure may also promote electrolyte disorders.

Keywords

Hyperglycaemia, Serum electrolytes, Renal dysfunction

How to cite this article :

Godwill Azeh Engwa, Friday Nweke Nwalo, Thom-Justus Chidera Atta ma, Micheal Chinweuba Abonyi, Emmanuela N. Akaniro-Ejim, Marian N. Unachukwu, et al.. INFLUENCE OF TYPE 2 DIABETES ON SERUM ELECTROLYTES AND RENAL FUNCTION INDICES IN PATIENTS. Journal of Clinical and Diagnostic Research [serial online] 2018 June [cited: 2018 Jun 23 ]; 12:BC13-BC16. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2018&month=June&volume=12&issue=6&page=BC13-BC16&id=11673

DOI and Others

DOI: 10.7860/JCDR/2018/35940.11673

Date of Submission: Feb 08, 2018
Date of Peer Review: Apr 11, 2018
Date of Acceptance: Apr 20, 2018
Date of Publishing: Jun 01, 2018

FINANCIAL OR OTHER COMPETING INTERESTS: None.

JCDR is now Monthly and more widely Indexed .
  • Emerging Sources Citation Index (Web of Science, thomsonreuters)
  • Index Copernicus ICV 2016: 132.37
  • SCOPUS
  • Academic Search Complete Database
  • Directory of Open Access Journals (DOAJ)
  • EBSCOhost
  • Embase & EMbiology
  • Google Scholar
  • HINARI Access to Research in Health Programme
  • Indian Science Abstracts (ISA)
  • Journal seek Database
  • Google
  • Popline (reproductive health literature)
  • www.omnimedicalsearch.com