Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

Users Online : 4363

Original article / research
Year : 2018 | Month : July | Volume : 12 | Issue : 7 | Page : OC20 - OC23

Association between Serum 25-Hydroxyvitamin D and Carotid Intima-Media Thickness in Acute Ischaemic Stroke: A Cross-Sectional Study

Mehboob Subhani Siddiqui, Ajay Kumar Mishra, Pragya Mishra, Davendra Kumar, Vasudha Jain

1. Professor, Department of Medicine, Era’s Lucknow Medical College, Lucknow, Uttar Pradesh, India. 2. Associate Professor, Department of Medicine, Era’s Lucknow Medical College, Lucknow, Uttar Pradesh, India. 3. Senior Resident, Department of Medicine, Era’s Lucknow Medical College, Lucknow, Uttar Pradesh, India. 4. Professor, Department of Medicine, Era’s Lucknow Medical College, Lucknow, Uttar Pradesh, India. 5. Assistant Professor, Department of Medicine, Era’s Lucknow Medical College, Lucknow, Uttar Pradesh, India.

Correspondence Address :
Dr. Ajay Kumar Mishra,
Associate Professor, Department of Medicine, Era's Lucknow Medical College, Lucknow-226012, Uttar Pradesh, India.
E-mail: dram1967@rediffmail.com

Abstract

Introduction: Vitamin D has been shown to have a strong association with both ischaemic stroke and cardiovascular disease. There is a scarcity of published data from Indian subcontinent on vitamin D status and its association with acute ischaemic stroke.

Aim: To study the association between serum 25-hydroxyvitamin D and Carotid Intima-Media Thickness (CIMT) in acute ischaemic stroke.

Materials and Methods: One hundred ten consecutive subjects with acute ischaemic stroke were selected as cases and 55 healthy age and gender match subjects were included as controls. Quantitative measurement of 25-OH vitamin D in serum and plasma samples was done. Common Carotid Artery (CCA) doppler images were obtained to measure Intima-Media Thickness (IMT) by using three different angle views for each vessel. Student’s t-test was used for comparison of continuous variables. The results of comparing the correlation between two continuous variables were indicated by the correlation coefficient (r) using correlation analysis.

Results: In the study population i.e., both in cases and controls, 59.39% subjects had vitamin D insufficiency, 34.44%had vitamin D deficiency and only 6.06% had Vitamin D levels within normal limits. The difference between the mean Vitamin D levels of cases (13.35±5.58 ng/mL) and controls (18.78±9.28 ng/mL) was found to be statistically significant (p<0.001). The difference mean CIMT among the cases (0.09±0.01 mm) and controls (0.07±0.01 mm) was also found to be statistically significant (p<0.001). Correlation between age and vitamin D levels was not statistically significant. A weak statistically significant negative correlation between CIMT and Vitamin D levels was found (r= -0.184 p=0.018).

Conclusion: The findings suggest that there is a probable association between low Vitamin D levels and acute ischaemic stroke. However, in view of presence of numerous confounding factors like diabetes, hypertension and obesity in our study a definite causal relationship cannot be established. Although both Vitamin D levels and CIMT show a strong association with acute ischaemic stroke; the linear relationship between Vitamin D levels and CIMT is rather weak.

Keywords

Atherosclerosis, Cerebrovasular disease, Vitamin D deficiency

How to cite this article :

Mehboob Subhani Siddiqui, Ajay Kumar Mishra, Pragya Mishra, Davendra Kumar, Vasudha Jain. ASSOCIATION BETWEEN SERUM 25-HYDROXYVITAMIN D AND CAROTID INTIMA-MEDIA THICKNESS IN ACUTE ISCHAEMIC STROKE: A CROSS-SECTIONAL STUDY. Journal of Clinical and Diagnostic Research [serial online] 2018 July [cited: 2018 Jul 21 ]; 12:OC20-OC23. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2018&month=July&volume=12&issue=7&page=OC20-OC23&id=11834

DOI and Others

DOI: 10.7860/JCDR/2018/35067.11834

Date of Submission: Dec 05, 2017
Date of Peer Review: Feb 15, 2018
Date of Acceptance: May 05, 2018
Date of Publishing: Jul 01, 2018

FINANCIAL OR OTHER COMPETING INTERESTS: None.

JCDR is now Monthly and more widely Indexed .
  • Emerging Sources Citation Index (Web of Science, thomsonreuters)
  • Index Copernicus ICV 2016: 132.37
  • SCOPUS
  • Academic Search Complete Database
  • Directory of Open Access Journals (DOAJ)
  • EBSCOhost
  • Embase & EMbiology
  • Google Scholar
  • HINARI Access to Research in Health Programme
  • Indian Science Abstracts (ISA)
  • Journal seek Database
  • Google
  • Popline (reproductive health literature)
  • www.omnimedicalsearch.com