Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2018 | Month : July | Volume : 12 | Issue : 7 | Page : BC30 - BC33

Evaluation and Comparison of Blood Parameters in Diabetic Patients with and without Peripheral Neuropathy

KP Ranjith, Bhanuchandar Potu, M Anju, Saleena Ummer Velladath, Manjunatha Hande

1. Postgraduate Student, Department of Medical Laboratory Technology, SOAHS, MAHE, Manipal, Karnataka, India. 2. Postgraduate Student, Department of Medical Laboratory Technology, SOAHS, MAHE, Manipal, Karnataka, India. 3. Assistant Professor, Department of Medical Laboratory Technology, SOAHS, MAHE, Manipal, Karnataka, India. 4. Associate Professor and Head, Department of Medical Laboratory Technology, SOAHS, MAHE, Manipal, Karnataka, India. 5. Professor and Head, Department of Medicine, KMC, Manipal, Karnataka, India.

Correspondence Address :
Dr. Saleena Ummer Velladath,
Associate Professor and Head, Department of Medical Laboratory Technology, SOAHS, MAHE, Manipal, Karnataka, India.
E-mail: saleena.ummer@maniapl.edu

Abstract

Introduction: Diabetic Peripheral Neuropathy (DPN) is the most prevalent and troublesome microvascular complication (50%) of Diabetes Mellitus (DM). The factors involved in the pathogenesis of diabetic neuropathy have not been understood completely. Studies have shown that neuronal dysfunction and inflammation play important roles in the development of DPN.

Aim: To evaluate and compare the inflammatory marker Neutrophil to Lymphocyte Ratio (NLR) and serum markers calcium, urea, and uric acid in diabetic patients with and without peripheral neuropathy.

Materials and Methods: We prospectively studied 118 diabetic patients who visited Kasturba Hospital, Manipal, Karnataka, India during December 2016- June 2017. After obtaining the ethical approval (IEC 791/2016), the patients were grouped into those with DPN (n=55) and without DPN (n=63). NLR and serum markers calcium, urea, and uric acid were estimated.

Results: The data were analysed using Student's t-test and Mann-Whitney U test and revealed a significantly high uric acid (p<0.001) and low calcium levels (p<0.001) in DPN patients compared to controls. The NLR was significantly high in DPN group {2.62 (2.3-3.1)} compared to that {1.9 (1.6-2.4)} in non-DPN group (p<0.001).

Conclusion: Monitoring the simple biomarkers routinely in diabetic patients may give an early signal to prevent DPN and thus better management of the patients.

Keywords

Biomarkers, Calcium, Diabetic peripheral neuropathy, Neutrophil lymphocyte ratio, Uric acid

How to cite this article :

KP Ranjith, Bhanuchandar Potu, M Anju, Saleena Ummer Velladath, Manjunatha Hande. EVALUATION AND COMPARISON OF BLOOD PARAMETERS IN DIABETIC PATIENTS WITH AND WITHOUT PERIPHERAL NEUROPATHY. Journal of Clinical and Diagnostic Research [serial online] 2018 July [cited: 2018 Jul 21 ]; 12:BC30-BC33. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2018&month=July&volume=12&issue=7&page=BC30-BC33&id=11842

DOI and Others

DOI: 10.7860/JCDR/2018/37075.11842

Date of Submission: May 10, 2018
Date of Peer Review: Jun 05, 2018
Date of Acceptance: Jun 23, 2018
Date of Publishing: Jul 01, 2018

FINANCIAL OR OTHER COMPETING INTERESTS: NONE.

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