Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2018 | Month : January | Volume : 12 | Issue : 1 | Page : BC01 - BC05

Thyroid Function among Children with Iron Deficiency Anaemia: Pre and Post Iron Replacement Therapy

Hosny MA El-Masry, Amira MM Hamed, Mohammed H Hassan, Hanan M Fayed, MH Abdelzaher

1. Professor, Department of Paediatrics, Faculty of Medicine, Al Azhar University, Assiut, Egypt. 2. Assistant Professor, Department of Paediatrics, Faculty of Medicine, Al Azhar University, Assiut, Egypt. 3. Lecturer, Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, South Valley University, Qena, Egypt. 4. Assistant Professor, Department of Clinical and Chemical Pathology, Faculty of Medicine, South Valley University, Qena, Egypt. 5. Lecturer, Department of Medical Biochemistry, Faculty of Medicine, Al Azhar University, Assiut branch, Egypt and Faculty Of Medicine-Prince Sattam Bin Abdulaziz University, Alkharg, Saudi Arabia.

Correspondence Address :
Dr. Mohammed H Hassan,
Lecturer, Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, South Valley University,
P.O. Box No. 83523, Qena, Egypt.
E-mail: mohammedhosnyhassaan@yahoo.com

Abstract

Introduction: Metabolism of thyroid hormones and iron is quite interdependent. Data indicates that Iron Deficiency (ID) could impair thyroid metabolism.

Aim: To investigate the possible occurrence of thyroid dysfunction among children with isolated Iron Deficiency Anaemia (IDA) of various severities, and test if the oral iron replacement therapy alone can reverse the associated thyroid function disturbances, if present or additional therapies are required.

Materials and Methods: This prospective study was carried out on 60 children selected from the attendants to the outpatient paediatric clinics of Al-Azhar University, Assiut and Qena university hospitals, Egypt, in addition to 60 controls. Complete blood count, thyroid profile, ferritin, iron, Total Iron Binding Capacity (TIBC), Transferrin Saturation% (TFS%), unsaturated iron binding capacity and Urinary Iodine Excretion (UIE) were assessed in the studied groups at baseline, then haemoglobin level and thyroid profile repeated among the studied patients after three months of oral iron supplementation therapy. Thyroid profile and ferritin were measured using commercially available Enzyme Linked Immunosorbent Assay (ELISA) kits; while, iron, TIBC and UIE were measured using colorimetric methods.

Results: Significant higher serum Thyroid Stimulating Hormone (TSH) levels with significant lower serum levels of Free Triiodothyronine (FT3) and Free Thyroxine (FT4) among patients versus controls (p<0.001 for all). Significant positive correlation between serum iron and FT3 (r=0.284, p<0.05) with significant negative correlations between TSH versus both serum iron (r=-0.635, p<0.001) and ferritin (r=-0.342, p<0.01). Significant decrease in the serum levels of TSH, with significant increase in the serum levels of FT3 and FT4 (p<0.001 for all) to euthyroid status following oral iron replacement therapy.

Conclusion: Subclinical or primary hypothyroidism can occur among children suffering from moderate to severe IDA, which is reversible following oral iron replacement therapy only, without need to add thyroid replacement therapy.

Keywords

Iron therapy, Microcytic anaemia, Thyroid hormones

How to cite this article :

Hosny MA El-Masry, Amira MM Hamed, Mohammed H Hassan, Hanan M Fayed, MH Abdelzaher. THYROID FUNCTION AMONG CHILDREN WITH IRON DEFICIENCY ANAEMIA: PRE AND POST IRON REPLACEMENT THERAPY. Journal of Clinical and Diagnostic Research [serial online] 2018 January [cited: 2018 Apr 23 ]; 12:BC01-BC05. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2018&month=January&volume=12&issue=1&page=BC01-BC05&id=11023

DOI and Others

DOI: 10.7860/JCDR/2018/32762.11023

Date of Submission: Sep 19, 2017
Date of Peer Review: Nov 16, 2017
Date of Acceptance: Dec 19, 2017
Date of Publishing: Jan 01, 2018

FINANCIAL OR OTHER COMPETING INTERESTS: None.

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