Can Mean Platelet Volume and Platelet Distribution Width be used as Predictive Markers for Impending Diabetic Vascular Complications?Correspondence Address :
Dr. R Lavanya Rajagopal,
B-Block, Door Number 902, SRM Medical Staff Quarters, SRM Medical College Hospital and Research Centre,
Kattanulathur, Chennai-603203, Tamil Nadu, India.
Introduction: Diabetes Mellitus (DM) has been considered as a prothrombotic state which has impact on a wide series of pathways regulating platelet function, the cornerstone is represented by increased platelet reactivity. Many hypothesis have attempted to explain the pathophysiological mechanism by which these hyperreactive platelets contribute to diabetic vascular complications. However, a comprehensive analysis of the relationship between platelet indices and diabetic status is still lacking.
Aim: To analyse platelet indices with glycaemic status in Type-2 DM patients and to establish the correlation between Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Fasting Blood Sugar (FBS) and Glycated haemoglobin (HbA1c) values.
Materials and Methods: A cross-sectional study was carried out in SRM Medical College Hospital and Research Centre, Chennai. Totally 450 subjects (150 controlled and 150 uncontrolled diabetics, 150 non-diabetics) were included and investigated for HbA1c, FBS and platelet indices.
Results: Diabetics had higher mean platelet count when compared to non-diabetics. MPV and PDW among uncontrolled diabetics were significantly higher than controlled diabetics and non-diabetics. MPV, PDW and platelet count showed a significant positive correlation with both HbA1c and FBS. We observed a significant difference in PDW and MPV when compared with various grades of HbA1c.
Conclusion: MPV and PDW are increased in diabetics. They are simple and cost-effective tools that can be used as a good indicator of platelet activation and an independent predictor of impending vascular complications in DM.
Diabetes, Fasting blood sugar, Glycated haemoglobin, Platelets
R Lavanya Rajagopal, Sundaram Arunachalam, Saleh Mohammed Abdullah, Vinothkumar Ganesan, Kumerasan Kathamuthu, Balaji Ramraj. CAN MEAN PLATELET VOLUME AND PLATELET DISTRIBUTION WIDTH BE USED AS PREDICTIVE MARKERS FOR IMPENDING DIABETIC VASCULAR COMPLICATIONS?. Journal of Clinical and Diagnostic Research [serial online] 2018 February [cited: 2018 Feb 23 ]; 12:EC01-EC05. Available from
Financial OR OTHER COMPETING INTERESTS: None.
Date of Submission: Sep 14, 2017
Date of Peer Review: Oct 03, 2017
Date of Acceptance: Dec 27, 2017
Date of Publishing: Feb 01 2018
- Emerging Sources Citation Index (Web of Science, thomsonreuters)
- Index Copernicus ICV 2016: 132.37
- Academic Search Complete Database
- Directory of Open Access Journals (DOAJ)
- Embase & EMbiology
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Popline (reproductive health literature)