Effect of Magnesium Sulphate and Dexmedetomidine on Blood Loss during Lumbar Spinal Fusion SurgeriesCorrespondence Address :
Assistant Professor, Department of Anaesthesia, Pondicherry Institute of Medical Sciences, Pondicherry-605014, India.
Introduction: Spine surgeries pose unique challenges to the anaesthesiologist in maintaining stable haemodynamics, relatively dry operative field and concerns over patient positioning during surgery.
Aim: The present study was aimed at comparing the effect of magnesium sulphate and Dexmedetomidine in minimizing blood loss and maintaining haemodynamic stability during spinal fusion surgeries.
Materials and Methods: Forty two patients aged 18-60 years of ASA 1 and 2 were randomly divided into two groups A and B. Group A received 30 mg/kg bolus followed by 10 mg/kg/hr of magnesium sulphate and group B received 1mcg/kg bolus followed by 0.4mcg/kg/hr of Dexmedetomidine till the end of surgery. The study drugs were started after intubation and positioning prone. Both the groups were observed for changes in haemodynamic parameters and for amount of blood loss. Blood loss was assessed by weighing the soaked sponges and gauze and calculating against the dry weight. A 1ml of blood was considered to be equal to 1gram weight. Statistical analysis was performed using SPSS version 21.
Results: The mean blood loss in group A was 516±8.029 ml and 499±5.34 mL in group B (p>0.05). The heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure were lower in group A compared to group B at various time intervals throughout the study (p<0.05) and it was statistically significant.
Conclusion: Both magnesium sulphate and Dexmedetomidine can be used for minimising blood loss during lumbar spinal fusion surgeries with Dexmedetomidine maintaining better haemodynamic stability.
Anaesthesia, Deformity correction surgeries, Haemodynamic stability
Titu George Oommen, Sivakumar Segaran, Mamie Zachariah, Ranjan RV, Anil Radhakrishnan Pillai, Sunilkumar Valasareddy, et al.. EFFECT OF MAGNESIUM SULPHATE AND DEXMEDETOMIDINE ON BLOOD LOSS DURING LUMBAR SPINAL FUSION SURGERIES. Journal of Clinical and Diagnostic Research [serial online] 2018 August [cited: 2018 Jul 19 ]; 12:UC01-UC05. Available from
Date of Submission: Jan 10, 2018
Date of Peer Review: Apr 09, 2018
Date of Acceptance: May 21, 2018
Date of Publishing: Aug 01, 2018
FINANCIAL OR OTHER COMPETING INTERESTS: None.
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