Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2018 | Month : August | Volume : 12 | Issue : 8 | Page : OC01 - OC04

Evaluation of Correlation between Serum Levels of Vitamin D and Coronary Artery Disease: An Existing Debate

Morteza Safi, Isa Khaheshi, Shadab Jafarzadeh, Mohammadreza Naderian, Mohammadali Akbarzadeh, Farbod Zahedi Tajrishi

1. Professor, Department of Cardiology, Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2. Assistant Professor, Department of Cardiology, Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 3. Resident, Department of Cardiology, Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 4. Resident, Department of Cardiology, Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; Cardiac Outcome Research and Education (CORE), Universal Scientific Education and Research Network (USERN), Tehran, Iran. 5. Assistant Professor, Department of Cardiology, Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 6. Physician, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.

Correspondence Address :
Dr. Farbod Zahedi Tajrishi,
Physician, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
E-mail: farbodzt@gmail.com

Abstract

Introduction: Coronary Artery Disease (CAD) is the global leading cause of death. Previous studies have been controversial on whether lower serum vitamin D levels could enhance the risk of CAD or its extent.

Aim: To evaluate the association between serum vitamin D levels and CAD by using a novel and promising angiographic index the Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score.

Materials and Methods: In the present cross-sectional study, 227 consecutive patients with suspected CAD referred for Coronary Angiography (CAG) were included. The patient’s clinical and demographic data were recorded. Blood sample was taken from each subject to measure serum 25-Hydroxy vitamin D (25(OH)D) concentration at the time of admission. Then CAG was performed and patients were divided according to their degree of CAD. Stenosis more than 50% in at least one main coronary artery was defined as significant CAD. Among the patients with significant CAD, the severity of the disease was assessed using the SYNTAX score. Statistical analyses were performed using chi-square and independent t-test. Analysis of Variance (ANOVA and Spearman’s correlation coefficient (?) and scatter plot were also used to detect the relationship between quantitative variables.

Results: The mean serum vitamin D concentration of the participants was 32.1±21 ng/mL. CAG confirmed 150 patients had significant and 77 had non-significant CAD. Mean serum vitamin D concentration was higher among the non-significant CAD group than the other group, but not statistically significant (p=0.94). In patients with significant CAD, the mean SYNTAX score was 11.7±6.8 and mean serum vitamin D was 30.3±12.4 ng/mL. Correlation analysis revealed a weak and not significant inverse correlation (r=-0.037, p=0.67) between serum vitamin D levels and the SYNTAX score.

Conclusion: The CAD and its severity may not be associated with serum vitamin D levels. Future large investigations will reveal more detailed results.

Keywords

25-hydroxyvitamin, Coronary angiography, SYNTAX score

How to cite this article :

Morteza Safi, Isa Khaheshi, Shadab Jafarzadeh, Mohammadreza Naderian, Mohammadali Akbarzadeh, Farbod Zahedi Tajrishi. EVALUATION OF CORRELATION BETWEEN SERUM LEVELS OF VITAMIN D AND CORONARY ARTERY DISEASE: AN EXISTING DEBATE. Journal of Clinical and Diagnostic Research [serial online] 2018 August [cited: 2018 Jul 23 ]; 12:OC01-OC04. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2018&month=August&volume=12&issue=8&page=OC01-OC04&id=11846

DOI and Others

DOI: 10.7860/JCDR/2018/35645.11846

Date of Submission: Jan 19, 2018
Date of Peer Review: Mar 28, 2018
Date of Acceptance: May 30, 2018
Date of Publishing: Aug 01, 2018

FINANCIAL OR OTHER COMPETING INTERESTS: NONE.

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