Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Case report
Year : 2018 | Month : August | Volume : 12 | Issue : 8 | Page : ED05 - ED06

Massive Lymphocytic Infiltration in the Uterus Mimicking Lymphoma-A Potential Diagnostic Challenge

Shailaja Shukla, Shivali Sehgal

1. Director Professor, Department of Pathology, Lady Hardinge Medical College, New Delhi, Delhi, India. 2. Assistant Professor, Department of Pathology and Blood Bank, Lady Hardinge Medical College, New Delhi, Delhi, India.

Correspondence Address :
Dr. Shivali Sehgal,
Assistant Professor, Department of Pathology, Lady Hardinge Medical College, New Delhi-110001, Delhi, India.
E-mail: shivaliseh gal@gmai


Leiomyoma with lymphoid infiltration is an uncommon lesion which mimics lymphoma. Although the polymorphous nature of the lymphoid infiltrate differentiates it from lymphoma, it may pose a diagnostic challenge at times. A 31-year-old female (Para 3, live issues 3) presented with menorrhagia. On sonography, a submucosal fibroid polyp measuring 2.5󫎽 cm arising from the anterior wall of the uterus was identified. Hysteroscopic polypectomy was carried out. Microscopy showed an exuberant lymphoid infiltrate in what appeared to be a leiomyoma. Numerous lymphoid follicles were observed, which on low magnification gave an impression of follicular lymphoma. Immunohistochemistry revealed their polymorphous character. It was diagnosed as leiomyoma with extensive lymphoid infiltration. It is important to know the range of histological alterations in leiomyomas, especially those with massive lymphoid infiltration since they simulate lymphoma clinically.


Immunohistochemistry, lymphoid infiltration, Uterine leiomyoma

How to cite this article :

Shailaja Shukla, Shivali Sehgal. MASSIVE LYMPHOCYTIC INFILTRATION IN THE UTERUS MIMICKING LYMPHOMA-A POTENTIAL DIAGNOSTIC CHALLENGE. Journal of Clinical and Diagnostic Research [serial online] 2018 August [cited: 2018 Jul 18 ]; 12:ED05-ED06. Available from

DOI and Others

DOI: 10.7860/JCDR/2018/31973.11921

Date of Submission: Jul 28, 2017
Date of Peer Review: Aug 28, 2017
Date of Acceptance: May 18, 2018
Date of Publishing: Aug 01, 2018


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