N-Terminal-pro Brain Natriuretic Peptide in Assessing the Severity of Stable Coronary Artery DiseaseCorrespondence Address :
Dr. Vijetha Shenoy Belle,
Assistant Professor, Department of Biochemistry, Kasturba Medical College, Madhav Nagar, Manipal-576104, Karnataka, India.
Introduction: Coronary Artery Disease (CAD) occurs due to atherosclerosis which results in progressive narrowing of coronary artery lumen. N-Terminal pro Brain Natriuretic Peptide (NT-proBNP) has been used as a marker of heart failure. However, its role in stable coronary artery disease without left ventricular dysfunction is limited.
Aim: To measure and compare the serum NT-proBNP levels in stable coronary artery patients and controls and to correlate serum NT-proBNP levels with severity of CAD.
Materials and Methods: The present study was conducted in Department of Biochemistry in collaboration with Department of Cardiology Kasturba Medical College, Manipal after the approval from Institutional Ethics Committee. A written consent was obtained from 86 study subjects (controls 36, cases 50). Serum NT-proBNP was measured using ELISA kit. Severity of CAD was graded by angiogram based Gensini scoring system. Mann-Whitney U-tests and spearmanís correlations were used. Serum NT-proBNP was expressed in median and interquartile range. The p-value<0.05 was considered to be significant.
Results: Median values of serum NT-proBNP levels in cases (151.9 pg/mL) were significantly higher as compared to that of controls (99.31 pg/mL), (p<0.001). There was a significant positive correlation of serum NT-proBNP with the respective Gensini scores in patients with stable coronary artery disease (r=0.263, p=0.014).
Conclusion: As Serum NT-proBNP levels were significantly associated with severity of stable CAD without left ventricular dysfunction, it can be a potential tool in effective management of stable CAD.
Enzyme linked immunosorbent assay, Gensini score, Natriuretic peptides
Vijetha Shenoy Belle, RV Krishnananda Prabhu, Ranjan K Shetty, Rajaram Prasad, Pragna Rao, Asha Kamath, et al.. N-TERMINAL-PRO BRAIN NATRIURETIC PEPTIDE IN ASSESSING THE SEVERITY OF STABLE CORONARY ARTERY DISEASE. Journal of Clinical and Diagnostic Research [serial online] 2018 August [cited: 2018 Aug 14 ]; 12:BC25-BC28. Available from
Date of Submission: Jan 16, 2018
Date of Peer Review: Mar 13, 2018
Date of Acceptance: Apr 19, 2018
Date of Publishing: Aug 01, 2018
FINANCIAL OR OTHER COMPETING INTERESTS: None.
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