Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2018 | Month : August | Volume : 12 | Issue : 8 | Page : BC25 - BC28

N-Terminal-pro Brain Natriuretic Peptide in Assessing the Severity of Stable Coronary Artery Disease

Vijetha Shenoy Belle, RV Krishnananda Prabhu, Ranjan K Shetty, Rajaram Prasad, Pragna Rao, Asha Kamath, Kriti Singh, Priyanka Datta

1. Assistant Professor, Department of Biochemistry, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Karnataka, India. 2. Professor, Department of Biochemistry, Kasturba Medical College Manipal Manipal Academy of Higher Education, Karnataka, India. 3. Professor, Department of Cardiology, Manipal Hospital, Bangalore, Karnataka, India. 4. Consultant Interventional Cardiologist, Asai Health Care, Salem, India. 5. Professor and Dean, Department of Biochemistry, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Karnataka, India. 6. Associate Professor and Head, Department of Statistics, Manipal Academy of Higher Education, Manipal, Karnataka, India. 7. Consultant, Department of Biochemistry, Columbia Asia Hospital, Bangalore, Karnataka, India. 8. Tutor, Department of Biochemistry, Nil Ratan Sarkar Medical College and Hospital, Kolkata, West Bengal, India.

Correspondence Address :
Dr. Vijetha Shenoy Belle,
Assistant Professor, Department of Biochemistry, Kasturba Medical College, Madhav Nagar, Manipal-576104, Karnataka, India.
E-mail: vijethashy@gmail.com

Abstract

Introduction: Coronary Artery Disease (CAD) occurs due to atherosclerosis which results in progressive narrowing of coronary artery lumen. N-Terminal pro Brain Natriuretic Peptide (NT-proBNP) has been used as a marker of heart failure. However, its role in stable coronary artery disease without left ventricular dysfunction is limited.

Aim: To measure and compare the serum NT-proBNP levels in stable coronary artery patients and controls and to correlate serum NT-proBNP levels with severity of CAD.

Materials and Methods: The present study was conducted in Department of Biochemistry in collaboration with Department of Cardiology Kasturba Medical College, Manipal after the approval from Institutional Ethics Committee. A written consent was obtained from 86 study subjects (controls 36, cases 50). Serum NT-proBNP was measured using ELISA kit. Severity of CAD was graded by angiogram based Gensini scoring system. Mann-Whitney U-tests and spearmanís correlations were used. Serum NT-proBNP was expressed in median and interquartile range. The p-value<0.05 was considered to be significant.

Results: Median values of serum NT-proBNP levels in cases (151.9 pg/mL) were significantly higher as compared to that of controls (99.31 pg/mL), (p<0.001). There was a significant positive correlation of serum NT-proBNP with the respective Gensini scores in patients with stable coronary artery disease (r=0.263, p=0.014).

Conclusion: As Serum NT-proBNP levels were significantly associated with severity of stable CAD without left ventricular dysfunction, it can be a potential tool in effective management of stable CAD.

Keywords

Enzyme linked immunosorbent assay, Gensini score, Natriuretic peptides

How to cite this article :

Vijetha Shenoy Belle, RV Krishnananda Prabhu, Ranjan K Shetty, Rajaram Prasad, Pragna Rao, Asha Kamath, et al.. N-TERMINAL-PRO BRAIN NATRIURETIC PEPTIDE IN ASSESSING THE SEVERITY OF STABLE CORONARY ARTERY DISEASE. Journal of Clinical and Diagnostic Research [serial online] 2018 August [cited: 2018 Aug 14 ]; 12:BC25-BC28. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2018&month=August&volume=12&issue=8&page=BC25-BC28&id=11939

DOI and Others

DOI: 10.7860/JCDR/2018/35594.11939

Date of Submission: Jan 16, 2018
Date of Peer Review: Mar 13, 2018
Date of Acceptance: Apr 19, 2018
Date of Publishing: Aug 01, 2018

FINANCIAL OR OTHER COMPETING INTERESTS: None.

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