Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2018 | Month : August | Volume : 12 | Issue : 8 | Page : BC19 - BC21

Serum 25-hydroxy Vitamin D levels as an Indicator of Bone Mineral Density in Osteoporosis

P Modagan, Santhi Silambanan, Gopinath Menon, P Arunalatha

1. Ph.D. Scholar, Department of Biochemistry, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India. 2. Professor and Head, Department of Biochemistry, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India. 3. Professor and Head, Department of Orthopaedics, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India. 4. Professor and Head, Department of Pathology, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India.

Correspondence Address :
Dr. P Modagan,
Ph.D. Scholar, Department of Biochemistry, Sri Ramachandra Medical College and Research Institute,
Chennai-600116, Tamil Nadu, India.
E-mail: pmodagan@gmail.com

Abstract

Introduction: Osteoporosis is a silent disease; the complications of disease are at an increased risk of fractures resulting in major health and economic impact of the disease. The 25-hydroxy vitamin D {25(OH) vitamin D} deficiency linked with osteoporosis and has been related to the low Bone Mineral Density (BMD).

Aim: The aim was to evaluate the 25(OH) vitamin D status and BMD in osteoporosis and to compare the status of vitamin D and BMD in osteoporosis group with normal control and osteopenia group.

Materials and Methods: A total of 90 subjects in the age group between 30 to 90 years of both sexes were included in the study. They were grouped into three, based on DEXA T-score of BMD as Group I -Normal bone mass, Group II-Osteopenia and Group III-Osteoporosis. The anthropometric data were measured and biochemical parameters were analysed for calcium, phosphorus and 25 (OH) vitamin D. One-way ANOVA was used for statistical interpretation.

Results: Statistical significant difference was observed in BMD at neck of femur (p<0.001), BMD at lumbar spine (p<0.001), 25(OH) vitamin D (p=0.009) and calcium (p=0.003) when compared between the three groups. In this study the 25(OH) vitamin D deficiency was higher in osteoporosis 19(63.3%) and the insufficiency was higher in osteopenia 13(43.3%) compared with other groups.

Conclusion: Decreased BMD performs a central role in the development of osteoporosis. The 25 (OH) vitamin D deficiencies may suggest the interrelation between bone remodeling disturbances in osteoporosis. The study shows that the 25(OH) vitamin D concentrations indicate the bone mineral status and thus the extent of the disease.

Keywords

Bone remodeling, DEXA scan, Osteopenia

How to cite this article :

P Modagan, Santhi Silambanan, Gopinath Menon, P Arunalatha. SERUM 25-HYDROXY VITAMIN D LEVELS AS AN INDICATOR OF BONE MINERAL DENSITY IN OSTEOPOROSIS. Journal of Clinical and Diagnostic Research [serial online] 2018 August [cited: 2018 Jul 19 ]; 12:BC19-BC21. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2018&month=August&volume=12&issue=8&page=BC19-BC21&id=11919

DOI and Others

DOI: 10.7860/JCDR/2018/35447.11919

Date of Submission: Jan 09, 2018
Date of Peer Review: Mar 11, 2018
Date of Acceptance: May 22, 2018
Date of Publishing: Aug 01, 2018

FINANCIAL OR OTHER COMPETING INTERESTS: As declared above.

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