Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Experimental Research
Year : 2017 | Month : November | Volume : 11 | Issue : 11 | Page : ZF01 - ZF04

Evaluation of Cellular Response to the Indigenously Fabricated Dental Magnet for Application in Prosthodontics- An Animal Study

Satyabodh Shesharaj Guttal, Ramesh Nadiger, Kaveri Hallikeri, Sudhindra S Kulkarni

1. Professor, Department of Prosthodontics, SDM College of Dental Sciences and Hospital, Dharwad, Karnataka, India. 2. Professor, Department of Prosthodontics, SDM College of Dental Sciences and Hospital, Dharwad, Karnataka, India. 3. Professor, Department of Oral and Maxillofacial Pathology, SDM College of Dental Sciences and Hospital, Dharwad, Karnataka, India. 4. Professor, Department of Oral Implantology, SDM College of Dental Sciences and Hospital, Dharwad, Karnataka, India.

Correspondence Address :
Dr. Satyabodh Shesharaj Guttal,
Professor, Department of Prosthodontics, SDM College of Dental Sciences and Hospital,
Sattur, Dharwad-580009, Karnataka, India.
E-mail: drsatyabodh@gmail.com

Abstract

Introduction: Prosthetic constructions retained by magnets play an important role in the application of dental removable prosthesis and orofacial epithesis. One of the issues during the introduction of these magnets into clinical practice is that they may exert some negative impact on the surrounding tissues. Therefore, the effect of the indigenous dental magnets on the cellular changes needs to be qualitatively evaluated.

Aim: To check the effect of indigenously fabricated dental magnets on the cellular changes in the dermis and epidermis of rabbits.

Materials and Methods: A total of five New Zealand rabbits were selected from the animal house of SDM Medical College, Dharwad. A small sub cutaneous incision was made on the back region of the rabbit on right and left side with a no. 15 Bard Parker (BP) blade under phenobarbitone anaesthesia. The skin layers were slightly dissected under the incision creating a pouch. Bare magnet without casing (control) was embedded in the pouch on one side and the teflon encased magnet (test) on the other side. Sutures were placed and post-operative care was taken. The obtained tissues were paraffinized and sections were stained with haematoxylin and eosin. The parameters assessed were thickness and keratinization of epidermis and arrangement of fibres and type of infalmatory cells in dermis. Data was subjected to statistical analysis. Mann-Whitney U test was performed.

Results: Statistically significant difference was observed in keratinization at 28 days and was still observed after 3 months. There was no difference in dermal fibres arrangement or chronic inflammation at the end of three months between the two groups. Haematoxylin and eosin stained sections from control and test showed mild chronic inflammatory response at 28 days. Inflammation subsided in three months in the test sample, whereas focal aggregates of inflammation were evident in control sections. Persistence of inflammatory cell reaction in control samples indicates mild cell toxicity induced by the magnet.

Conclusion: To conclude indigenously fabricated dental magnet did not show host inflammatory reaction in the animal study model over the control magnet.

Keywords

Biomedical device, Cytotoxicity, Inflammation

How to cite this article :

Satyabodh Shesharaj Guttal, Ramesh Nadiger, Kaveri Hallikeri, Sudhindra S Kulkarni. EVALUATION OF CELLULAR RESPONSE TO THE INDIGENOUSLY FABRICATED DENTAL MAGNET FOR APPLICATION IN PROSTHODONTICS- AN ANIMAL STUDY. Journal of Clinical and Diagnostic Research [serial online] 2017 November [cited: 2018 Jan 23 ]; 11:ZF01-ZF04. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=November&volume=11&issue=11&page=ZF01-ZF04&id=10899

DOI and Others

DOI: 10.7860/JCDR/2017/29287.10899

Date of Submission: Apr 13, 2017
Date of Peer Review: Jun 22, 2017
Date of Acceptance: Sep 18, 2017
Date of Publishing: Nov 01, 2017

FINANCIAL OR OTHER COMPETING INTERESTS: None.

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