Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : November | Volume : 11 | Issue : 11 | Page : TC13 - TC16

Evaluation of Liver Stiffness in Healthy Individuals by Sonoelastography

Veerendra Kumar Sharma, Ankur Malhotra, Tarun Kumar Chauhan

1. Assistant Professor, Department of Radiology, Shri Mahant Indiresh Hospital, Dehradun, Uttarakhand, India. 2. Assistant Professor, Department of Radiology, Shri Mahant Indiresh Hospital, Dehradun, Uttarakhand, India. 3. Postgraduate Student, Department of Radiology, Shri Mahant Indiresh Hospital, Dehradun, Uttarakhand, India.

Correspondence Address :
Dr. Ankur Malhotra,
Assistant Professor, Department of Radiology, Shri Mahant Indiresh Hospital, Patel Nagar,
Dehradun-248001, Uttarakhand, India.
E-mail: drankur.m7@gmail.com

Abstract

Introduction: Successfully detecting and managing Liver Fibrosis (LF) at an early phase can significantly improve the prognosis of patients in clinical practice; therefore, accurately assessing the degree of fibrosis when the disease is at an early stage is extremely important. However, the normal range of Liver Stiffness (LS) on Point Shear Wave Elastography (PSWE) is not well established.

Aim: The present study aimed to quantitatively evaluate and compare sonoelastographic values of liver stiffness in healthy individuals without any clinical complaints.

Materials and Methods: A prospective cross-sectional study was done from November 2014 to January 2017 in a tertiary care hospital in Uttarakhand region. The mean kilopascal value of 10 consecutive measurements were used as representative value for each healthy individual. The effects of potential confounding factors (age, gender, hepatic steatosis, and BMI) on liver elasticity were evaluated. Results were evaluated using SPSS© for windows™ Vs 23 (IBM™ Corp NY) and Microsoft excel™ 2007(Microsoft® Inc USA). Student’s t-test was used to check the significance of difference between two parameters. ANOVA followed by Tukey’s HSD test was used to test the significance of difference between more than two parameters in parametric data.

Results: A total of 207 healthy individuals out of which 59 had fatty liver (incidentally detected) formed a part of this study. Reference range of liver stiffness in total study population was 4.48±0.78 kPa. Liver stiffness in males was 4.56±0.76 kPa and in females was 4.32±0.80 kPa. Reference range of liver stiffness for fatty liver was 4.59±0.84 kPa and for healthy liver was 4.47±0.75.

Conclusion: Normal reference range of liver stiffness in healthy individuals in Uttarakhand region was 4.48±0.78 kPa. Of all the confounding factors only males have significant higher liver elasticity as compared to females. Other confounding factors have no significant effect on liver elasticity.

Keywords

Liver, Fatty liver, Fibrosis, Sonoelastography

How to cite this article :

Veerendra Kumar Sharma, Ankur Malhotra, Tarun Kumar Chauhan. EVALUATION OF LIVER STIFFNESS IN HEALTHY INDIVIDUALS BY SONOELASTOGRAPHY. Journal of Clinical and Diagnostic Research [serial online] 2017 November [cited: 2018 Jan 19 ]; 11:TC13-TC16. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=November&volume=11&issue=11&page=TC13-TC16&id=10869

DOI and Others

DOI: 10.7860/JCDR/2017/29777.10869

Date of Submission: Jun 17, 2017
Date of Peer Review: Jul 18, 2017
Date of Acceptance: Oct 04, 2017
Date of Publishing: Nov 01, 2017

FINANCIAL OR OTHER COMPETING INTERESTS: None.

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