Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

Users Online : 22908

Original article / research
Year : 2017 | Month : November | Volume : 11 | Issue : 11 | Page : QC12 - QC16

NT-proBNP: A Biochemical Marker of Maternal Complications in Pre-eclampsia

Supriya Kumari, Mamta Gupta, Harsh Vardhan, Vandana Saini, S.K. Gupta

1. Trainee, Department of Obstetrics and Gynaecology, Hindu Rao Hospital and NDMC Medical College, New Delhi, India. 2. Senior Consultant and Head, Department of Obstetrics and Gynaecology, Hindu Rao Hospital and NDMC Medical College, New Delhi, India. 3. Senior Biochemist, Department of Biochemistry, Hindu Rao Hospital and NDMC Medical College, New Delhi, India. 4. Senior Specialist, Department of Obstetrics and Gynaecology, Hindu Rao Hospital and NDMC Medical College, New Delhi, India. 5. Professor, Department of Biochemistry, Maulana Azad Medical College, New Delhi, India.

Correspondence Address :
Dr. Supriya Kumari,
C-22, Vikaspuri-110018, New Delhi, India.
E-mail: supriya.oct29@gmail.com

Abstract

Introduction: Elevated serum levels of NT-proBNP (N terminal pro-Brain Natriuretic Peptide) are associated with Pre-Eclampsia (PE) and its complications.

Aim: To evaluate NT-proBNP in women with PE and correlate its levels with maternal outcome.

Materials and Methods: A total 90 out of which 45 women with PE (Group A) and 45 normotensive healthy pregnant women with singleton pregnancy (Group B) were enrolled. NT-proBNP was estimated at term or just before induction of labour or in early labour. These women were followed till 48 hours postpartum. Maternal outcome was recorded and analysed using statistical tests like Student t-test, Mann-whitney, ANOVA, Kruskal Wallis, Pearson and Spearman correlation.

Results: Significant elevated serum levels of NT-proBNP were seen in PE women than controls (mean 439.47431.99 and 99.4037.89 respectively) (p-value <0.001). Severity and early onset of PE was associated with further increased serum NT-proBNP levels. In Group B none of the women developed any complication whereas, in Group A 19/45 (42.22%) women had a total of 31 complications. Forty percent of these PE women had maternal complications and elevated NT-proBNP levels above 500 pg/mL. Cardiovascular complications were observed in 4/45 women with NT-proBNP levels of 770 pg/mL and above. The positive predictive value for NT-proBNP for detecting complications was 83.33% at a cut-off level of 500 pg/mL. The negative predictive value was 92.85% at a cut-off level of 100 pg/mL. Women in Group A with early onset PE, who did not develop maternal complications, had low serum NT-proBNP. Women without severe features of PE (n=12) in Group A who developed complications, had elevated NT-proBNP (mean 434307.219 pg/mL) than those who had no complication (mean NT-proBNP 80.6637.54 pg/mL).

Conclusion: NT-proBNP is a useful marker for predicting maternal complications and risk stratification for optimum maternal outcome in a PE women.

Keywords

Hypertensive disorders, Maternal complications, N terminal pro-brain natriuretic peptide

How to cite this article :

Supriya Kumari, Mamta Gupta, Harsh Vardhan, Vandana Saini, S.K. Gupta. NT-PROBNP: A BIOCHEMICAL MARKER OF MATERNAL COMPLICATIONS IN PRE-ECLAMPSIA. Journal of Clinical and Diagnostic Research [serial online] 2017 November [cited: 2018 Jan 22 ]; 11:QC12-QC16. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=November&volume=11&issue=11&page=QC12-QC16&id=10855

DOI and Others

DOI: 10.7860/JCDR/2017/28713.10855

Date of Submission: Apr 01, 2017
Date of Peer Review: May 17, 2017
Date of Acceptance: Aug 08, 2017
Date of Publishing: Nov 01, 2017

FINANCIAL OR OTHER COMPETING INTERESTS: None.

JCDR is now Monthly and more widely Indexed .
  • Emerging Sources Citation Index (Web of Science, thomsonreuters)
  • Index Copernicus ICV 2016: 132.37
  • SCOPUS
  • Academic Search Complete Database
  • Directory of Open Access Journals (DOAJ)
  • EBSCOhost
  • Embase & EMbiology
  • Google Scholar
  • HINARI Access to Research in Health Programme
  • Indian Science Abstracts (ISA)
  • Journal seek Database
  • Google
  • Popline (reproductive health literature)
  • www.omnimedicalsearch.com