Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

Users Online : 23501

Case Series
Year : 2017 | Month : November | Volume : 11 | Issue : 11 | Page : OR01 - OR04

Clinical Spectrum of Autoimmune Encephalitis: Case Series from Western Rajasthan

Pratibha Prasad, Amita Bhargava, Shubhakaran Khichar, Vikas Kumar Gupta

1. Senior Resident, Department of Neurology, Dr. S.N. Medical College, Jodhpur, Rajasthan, India. 2. Professor and Head, Department of Neurology, Dr. S.N. Medical College, Jodhpur, Rajasthan, India. 3. Professor, Department of Neurology, Dr. S.N. Medical College, Jodhpur, Rajasthan, India. 4. Junior Resident, Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Correspondence Address :
Dr. Pratibha Prasad,
Room No. 9, PG Hostel, Mahatma Gandhi Hospital, Jodhpur-342001, Rajasthan, India.
E-mail: pratibhaprasad12@gmail.com

Abstract

Autoimmune Encephalitis (AE) is a challenging diagnosis due to the similarities in the clinical, imaging and laboratory findings among many forms of infectious encephalitis. Patients generally have impaired memory and cognition and neuropsychiatric manifestations over a period of days or weeks. However, a careful history and examination may show early clues to particular autoimmune causes, such as seizures, dystonia, abnormal movements, psychosis, or the presence of particular tumours. Appropriate autoantibody testing can confirm specific diagnoses. When infectious etiology is excluded, AE must be considered which is potentially reversible with immunomodulation therapy. Here, we describe five patients with AE: four auto-antibody positive, one auto-antibody negative, treated during last 20 months, presenting with different syndromes and first ever reported from western Rajasthan. Hence, this case series highlights the importance of early diagnosis and appropriate treatment leading to significant reduction of mortality and morbidity.

Keywords

Neuronal autoantibodies, Psychiatric symptoms, Seizure

How to cite this article :

Pratibha Prasad, Amita Bhargava, Shubhakaran Khichar, Vikas Kumar Gupta. CLINICAL SPECTRUM OF AUTOIMMUNE ENCEPHALITIS: CASE SERIES FROM WESTERN RAJASTHAN. Journal of Clinical and Diagnostic Research [serial online] 2017 November [cited: 2018 Jan 18 ]; 11:OR01-OR04. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=November&volume=11&issue=11&page=OR01-OR04&id=10897

DOI and Others

DOI: 10.7860/JCDR/2017/28695.10897

Date of Submission: May 23, 2017
Date of Peer Review: Jun 29, 2017
Date of Acceptance: Oct 04, 2017
Date of Publishing: Nov 01, 2017

FINANCIAL OR OTHER COMPETING INTERESTS: None.

JCDR is now Monthly and more widely Indexed .
  • Emerging Sources Citation Index (Web of Science, thomsonreuters)
  • Index Copernicus ICV 2016: 132.37
  • SCOPUS
  • Academic Search Complete Database
  • Directory of Open Access Journals (DOAJ)
  • EBSCOhost
  • Embase & EMbiology
  • Google Scholar
  • HINARI Access to Research in Health Programme
  • Indian Science Abstracts (ISA)
  • Journal seek Database
  • Google
  • Popline (reproductive health literature)
  • www.omnimedicalsearch.com