Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : November | Volume : 11 | Issue : 11 | Page : OC25 - OC28

A Comparative Study of Single Versus Multiple Cysts of Neurocysticercosis Based on their Clinico-Serological Profile

Ishwar Agrawal, Manish Mittal, Garima Mittal

1. Postgraduate Student, Department of Medicine, Himalyan Institute of Medical Sciences, Swami Rama Himalyan University, Dehradun, Uttarakhand, India. 2. Assistant Professor, Department of Neurology, Himalyan Institute of Medical Sciences, Swami Rama Himalyan University, Dehradun, Uttarakhand, India. 3. Associate Professor, Department of Microbiology, Himalyan Institute of Medical Sciences, Swami Rama Himalyan University, Dehradun, Uttarakhand, India.

Correspondence Address :
Dr. Garima Mittal,
Associate Professor, Department of Microbiology, Himalyan Institute of Medical Sciences,
Swami Rama Himalyan University, Dehradun-248016, Uttarakhand, India.
E-mail: garimamittal80@gmail.com

Abstract

Introduction: Neurocysticercosis (NCC) is a common disease in developing countries. Its diagnosis is based on clinical, epidemiological, imaging findings and laboratory tests.

Aim: To study and compare the clinical profile and diagnostic utility of NCC IgG ELISA in patients with single and multiple neurocysticercosis.

Materials and Methods: This cross-sectional study was conducted in the Department of General Medicine, Himalayan Institute of Medical Science (HIMS), Swami Ram Nagar, Dehradun, over a period of 12 months from August 2014 to July 2015. Patients were grouped into those with single NCC and multiple NCC based on their radio imaging findings. A total number of 60 patients, 30 in each group were taken in the study and their clinical profiles were studied. Serum Immunoglobulin G(IgG) Enzyme-Linked Immunosorbent Assay (ELISA) test was applied on both the groups and serological profile was thus compared.

Results: Most commonly affected age group was 18 to 35 years of age (60%). Most common symptom at presentation was seizure (53%). Out of 60 patients, 39 suffered from generalized tonic-clonic seizures. Status epilepticus was found exclusively in patients with multiple NCC (26.6%). Sensitivity of serum IgG ELISA was 53.3% amongst single NCC and 76.7% amongst multiple NCC.

Conclusion: NCC may present with varied clinical features. No sign or symptom is pathognomic of the disease entity. Diagnostic tests are the only method to clinch the diagnosis. Detection of specific antibodies in patients with NCC is a useful tool for diagnosis, especially when radio imaging facilities are not available or inconclusive. Serological tests are useful if they are positive. Negative tests, however, do not exclude the diagnosis of NCC.

Keywords

Taenia solium, Tonic-clonic seizures, Idiopathic epilepsy, Status epilepticus

How to cite this article :

Ishwar Agrawal, Manish Mittal, Garima Mittal. A COMPARATIVE STUDY OF SINGLE VERSUS MULTIPLE CYSTS OF NEUROCYSTICERCOSIS BASED ON THEIR CLINICO-SEROLOGICAL PROFILE. Journal of Clinical and Diagnostic Research [serial online] 2017 November [cited: 2018 Jan 24 ]; 11:OC25-OC28. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=November&volume=11&issue=11&page=OC25-OC28&id=10888

DOI and Others

DOI: 10.7860/JCDR/2017/28708.10888

Date of Submission: Mar 25, 2017
Date of Peer Review: May 26, 2017
Date of Acceptance: Oct 16, 2017
Date of Publishing: Nov 01, 2017

FINANCIAL OR OTHER COMPETING INTERESTS: None.

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