Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : November | Volume : 11 | Issue : 11 | Page : GC01 - GC04

Association of Lin-28A rs3811464 Variant with Susceptibility to Type 2 Diabetes

Mona Khodabandeh, Hamid Ghaedi, Behnam Alipoor, Taghi Golmohammadi

1. Postgraduate Student, Department of Cell and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran. 2. Assistant Professor, Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 3. Assistant Professor, Department of Laboratory Sciences, Faculty of Paramedicine, Yasuj University of Medical Sciences, Yasuj, Iran. 4. Associate Professor, Department of Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Correspondence Address :
Dr. Taghi Golmohammadi,
Associate Professor, Department of Biochemistry, Faculty of Medicine, School of Medicine,
Tehran University of Medical Sciences, Tehran-1417653761, Iran.
E-mail: golmoham@sina.tums.ac.ir

Abstract

Introduction: It has been suggested that Lin-28A and the let-7 microRNA family (Lin-28/let-7 axis) play a critical role in the control of glucose metabolism, insulin sensitivity and resistance to diabetes.

Aim: This case-control study aimed at evaluating the association between Lin-28 rs3811464 polymorphism and the susceptibility to Type 2 Diabetes (T2D) in a sample of Iranian population.

Materials and Methods: This study involved 172 T2D patients and 160 non-diabetic age and gender-matched controls. Lin 28A rs3811464 genotypes were determined by Polymerase Chain Reaction–Restriction Fragment Length Polymorphism (PCR-RFLP) technique.

Results: The results showed that the frequency of the AA genotype was significantly higher in control subjects than in diabetic patients (13.12% vs. 4.65%). In addition, binary logistic regression analysis revealed that rs3811464-AA genotype was significantly associated to T2D after adjustment for BMI, age and lipid profiles. Indeed, subjects with AA genotype were less likely to develop T2D than GG and AG subjects (OR of 0.26, 95% CI 0.10-0.66, p=0.005).

Conclusion: The findings of our study suggest that the Lin 28A rs3811464 is associated with type 2 diabetes susceptibility and subjects with AA genotypes were less likely to develop T2D diabetes.

Keywords

Diabetes risk, Genetic association study, Single nucleotide polymorphism

How to cite this article :

Mona Khodabandeh, Hamid Ghaedi, Behnam Alipoor, Taghi Golmohammadi. ASSOCIATION OF LIN-28A RS3811464 VARIANT WITH SUSCEPTIBILITY TO TYPE 2 DIABETES. Journal of Clinical and Diagnostic Research [serial online] 2017 November [cited: 2018 Jan 21 ]; 11:GC01-GC04. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=November&volume=11&issue=11&page=GC01-GC04&id=10890

DOI and Others

DOI: 10.7860/JCDR/2017/25374.10890

Date of Submission: Nov 22, 2016
Date of Peer Review: Jan 27, 2017
Date of Acceptance: May 11, 2017
Date of Publishing: Nov 01, 2017

FINANCIAL OR OTHER COMPETING INTERESTS: None.

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