Protocol for Dental Management in a Patient with Glucose- 6-Phosphate Dehydrogenase DeficiencyCorrespondence Address :
Dr. Balakrishnan Venkatesh,
2/102, East Coast Road, Uthandi, Chennai-600119, Tamil Nadu, India.
Glucose-6-Phosphate Dehydrogenase (G6PD) enzyme deficiency is the most common inherited genetic disorder affecting RBCs in humans. The disorder is characterised by inability of RBC to maintain a balanced redox state when challenged by oxidative stresses like drugs, infections and certain food substances leading to severe haemolytic anaemia which complicates any therapeutic management in these patients. This article reports on a successful endodontic management of a 36-year-old class III G6PD deficient male patient with deep carious lesion in left mandibular first molar tooth (36). Considering there is no protocol precedence in dental literature, in consultation with the physician/haemotologist a three step protocol for safe and efficient dental management is proposed.
Acute haemolytic anaemia, Endodontic therapy, Favism, G6PD deficiency, Red blood cells
Ramachandran Anil Kumar, Balakrishnan Venkatesh, Chellaswamy Savarimalai Karumaran, Meenakshi Sundaram Rajasekaran, Padmanabhan Shankar. PROTOCOL FOR DENTAL MANAGEMENT IN A PATIENT WITH GLUCOSE- 6-PHOSPHATE DEHYDROGENASE DEFICIENCY. Journal of Clinical and Diagnostic Research [serial online] 2017 October [cited: 2018 Jan 17 ]; 11:ZD09-ZD11. Available from
Date of Submission: Jun 29, 2017
Date of Peer Review: Jul 21, 2017
Date of Acceptance: Aug 30, 2017
Date of Publishing: Oct 01, 2017
FINANCIAL OR OTHER COMPETING INTERESTS: None.
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