Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : October | Volume : 11 | Issue : 10 | Page : SC14 - SC17

Altered Adaptive Cellular Immune Function in a Group of Egyptian Children with Autism

Engy A. Ashaat, Khaled H. Taman, Naglaa Kholoussi, Mona O. El Ruby, Moushira Erfan Zaki, Maged A. El Wakeel, Neveen A. Ashaat, Samira Ismail Ibrahim

1. Researcher, Department of Clinical Genetics, National Research Centre, Giza, Cairo, Egypt. 2. Professor, Department of Pediatrics, Institute of Postgraduate Childhood Studies, Cairo, Egypt. 3. Professor, Department of Immunogenetics, National Research Centre, Giza, Cairo, Egypt. 4. Professor, Department of Clinical Genetics, National Research Centre, Giza, Cairo, Egypt. 5. Professor, Department of Biological Anthropology, National Research Centre, Giza, Cairo, Egypt. 6. Associate Professor, Department of Child Health, National Research Centre, Giza, Cairo, Egypt. 7. Associate Professor, Department of Clinical Genetics, Faculty of Woman for Science, Ain Shams University, Cairo, Egypt. 8. Professor, Department of Clinical Genetics, National Research Centre, Giza, Cairo, Egypt.

Correspondence Address :
Dr. Maged A. El Wakeel,
El Buhooth Street, Dokki, Giza, Cairo, Egypt.
E-mail: maged_elwakeel@yahoo.com

Abstract

Introduction: There is a growing evidence of immune system alteration in children with Autism Spectrum Disorder (ASD). These changes may include higher levels of pro-inflammatory cytokines in plasma, Cerebrospinal Fluid (CSF) and brain cells.

Aim: To evaluate the imbalance of the immune system in autism through correlating some immunological markers (C3, C4, CD4, IL12 and IL17) with severity of ASD.

Materials and Methods: The current case-control study included 120 subjects, 60 autistic children and 60 healthy control obtained from the Clinical Genetics Clinic, National Research Centre, Egypt from the period between December 2014 to December 2016. All candidates were subjected to full clinical evaluation in addition to ElectroEncephaloGraphy (EEG), hearing test and estimation of interleukins (IL12- IL17), C3-C4, CD4 levels in blood samples. Independent t-test, Chi-square test or McNemar test were used to analyse the data.

Results: The levels of IL12 (27.47 7.15) and IL17 (1630.46310.42) were significantly higher, (p= 0.026, 0.005) respectively, while levels of CD4 were significantly lower (37.93 3.25), (p<0.001) in autistic children compared to controls; however, there was no significant difference in C3 and C4 between the two groups. High statistically significant difference between autistic children with moderate and severe ASD in CD4 levels were seen, (p=0.018).

Conclusion: Autistic children may suffer from immunological dysfunction. Further efforts should be exerted to find out the relation between immune imbalance and the progression of ASD.

Keywords

Autism spectrum disorder, Complement system, Cytokines, Immunological disorders

How to cite this article :

Engy A. Ashaat, Khaled H. Taman, Naglaa Kholoussi, Mona O. El Ruby, Moushira Erfan Zaki, Maged A. El Wakeel, et al.. ALTERED ADAPTIVE CELLULAR IMMUNE FUNCTION IN A GROUP OF EGYPTIAN CHILDREN WITH AUTISM. Journal of Clinical and Diagnostic Research [serial online] 2017 October [cited: 2018 Jan 23 ]; 11:SC14-SC17. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=October&volume=11&issue=10&page=SC14-SC17&id=10782

DOI and Others

DOI: 10.7860/JCDR/2017/28124.10782

Date of Submission: Mar 05, 2017
Date of Peer Review: Apr 08, 2017
Date of Acceptance: Sep 13, 2017
Date of Publishing: Oct 01, 2017

FINANCIAL OR OTHER COMPETING INTERESTS: None.

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