Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : October | Volume : 11 | Issue : 10 | Page : DC01 - DC03

Predictive Role of Proteinuria in Urinary Tract Infection

Tanisha Bharara, Abha Sharma, Renu Gur, Shalini Dewan Duggal, Pragnya Paramita Jena, Avinash Kumar

1. Senior Resident, Department of Microbiology, BSA Hospital, New Delhi, India. 2. Associate Professor, Department of Microbiology, BSA Medical College and Hospital, New Delhi, India. 3. Senior Specialist and Head, Department of Microbiology, BSA Hospital, New Delhi, India. 4. Specialist, Department of Microbiology, BSA Hospital, New Delhi, India. 5. Senior Resident, Department of Microbiology, BSA Hospital, New Delhi, India. 6. Senior Resident, Department of Microbiology, BSA Hospital, New Delhi, India.

Correspondence Address :
Dr. Renu Gur,
Senior Resident, Department of Microbiology, BSA Hospital, New Delhi-110085, India.
E-mail: renugur@hotmail.com

Abstract

Introduction: Urine culture is considered as holy grail in diagnosis of Urinary Tract Infection (UTI). However, the significance of preliminary urinalysis cannot be neglected.

Aim: To evaluate proteinuria as a predictor of UTI.

Materials and Methods: This study was conducted at the Department of Microbiology, Dr. Baba Saheb Ambedkar Hospital, New Delhi, India, over a period of three months (April 2015 to June 2015). Urine specimens from clinically suspected cases of UTI were analysed microscopically for pyuria and by reagent strip test for albuminuria. The results were correlated with urine culture findings. Antimicrobial resistance for various antimicrobials was compared among proteinuria positive and negative cases. Statistical analysis was done by Fisher’sexact test and p-value was calculated. A p-value =0.05 was considered significant.

Results: A total of 369 urine samples received for both routine microscopy and culture, out of which 73 were proteinuria positive. Out of these 73 samples, 32 were culture positive while 41 were culture negative. Among culture positive, 62.5% patients were symptomatic (20/32) while 37.5% were asymptomatic (12/32). Their age ranged from five months to 83 years. Male to female ratio was 1:1.5. Association between culture positivity and proteinuria was statistically significant (p<0.001) with 43.8% positive predictive value. Pyuria was observed in 42.5% cases. Out of 296 proteinuria negative samples, 36 were culture positive. ß-lactam antibiotic resistance among proteinuria positive cases and chloramphenicol resistance among proteinuria negative cases was significantly high.

Conclusion: Proteinuria as a urinalysis parameter may have good predictive power combined with the clinical presentation to diagnose UTI.

Keywords

Antimicrobial resistance, Pyuria, Urine albumin, Urine culture

How to cite this article :

Tanisha Bharara, Abha Sharma, Renu Gur, Shalini Dewan Duggal, Pragnya Paramita Jena, Avinash Kumar. PREDICTIVE ROLE OF PROTEINURIA IN URINARY TRACT INFECTION. Journal of Clinical and Diagnostic Research [serial online] 2017 October [cited: 2018 Jan 18 ]; 11:DC01-DC03. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=October&volume=11&issue=10&page=DC01-DC03&id=10720

DOI and Others

DOI: 10.7860/JCDR/2017/29615.10720

Date of Submission: May 01, 2017
Date of Peer Review: Jun 06, 2017
Date of Acceptance: Aug 01, 2017
Date of Publishing: Oct 01, 2017

FINANCIAL OR OTHER COMPETING INTERESTS: None.

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