Hypovitaminosis D is Associated with Gestational Diabetes MellitusCorrespondence Address :
Dr. Mamta Gupta,
A-18, Greenview Aptt., Sector 9, Rohini-110085, Delhi, India.
Introduction: Vitamin D deficiency has been shown to cause expression of insulin gene resulting in high insulin synthesis and secretion. It also decreases insulin resistance, thus affecting abnormal glucose metabolism and diabetes.
Aim: To estimate total 25-hydroxy vitamin D levels in pregnant women and to find its association with Gestational Diabetes Mellitus (GDM).
Materials and Methods: Fifty-four antenatal women were randomly enrolled at 24-28 weeks gestation after conforming to exclusion criteria. Serum vitamin D, two-hour 75 grams glucose and postprandial plasma glucose levels were estimated in all women at the time of enrollment. GDM was diagnosed with plasma glucose level >140 mg/dL (Group A). Rest of the women constituted Group B or control group. They were followed up till delivery. Vitamin D status and fetomaternal outcome was evaluated.
Results: Hypovitaminosis D was found in 93% of women. There were 38.8% women (n=21) in GDM group compared to 61.2% (n=33) in control group. Vitamin D was significantly low in Group A than B (p-value 0.004). None of the women in Group A had vitamin D levels of 10 ng/mL and above compared to 37.2% in Group B. Severe vitamin D deficient women (levels <5 ng/mL) had a risk ratio of 5.647 for developing GDM. A negative correlation was observed between vitamin D levels and plasma glucose levels.
Conclusion: Hypovitaminosis D was associated with development of GDM.
Modifiable risk factors, Plasma glucose levels, Vitamin D deficiency
Arijit Debnath, Mamta Gupta, Sanjay Jain, SupriyaKumari,
Tamoghna Biswas, Somosri Ray, et al.. HYPOVITAMINOSIS D IS ASSOCIATED WITH GESTATIONAL DIABETES MELLITUS. Journal of Clinical and Diagnostic Research [serial online] 2017 October [cited: 2017 Dec 15 ]; 11:QC01-QC03. Available from
Date of Submission: Feb 10, 2017
Date of Peer Review: Mar 22, 2017
Date of Acceptance: May 09, 2017
Date of Publishing: Oct 01, 2017
FINANCIAL OR OTHER COMPETING INTERESTS: None.
- PubMed Central® (PMC)New
- Academic Search Complete Database
- Chemical Abstracts Service
- Directory of Open Access Journals (DOAJ)
- Embase & EMbiology
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Open J-Gate
- Popline (reproductive health literature)