Gamma Glutamyl Transpeptidase, Smokeless Tobacco, Chronic Periodontitis: Exploring the LinkCorrespondence Address :
Dr. Arati C Koregol,
Professor, Department of Periodontics, P.M. Nadagouda Memorial Dental College and Hospital, Bagalkot-587101, Karnataka India.
Introduction: Oxidative Stress (OS) is implicated in the pathogenesis of many systemic and oral diseases such as periodontal disease. Smokeless tobacco extract produces apoptosis and causes an imbalance between reactive oxygen species and antioxidants, such as Gamma Glutamyl Transpeptidase (GGT). Epidemiological research implied serum GGT within its normal range to be an early sensitive enzyme related to OS.
Aim: To assess how GGT fares as a biomarker in periodontitis subjects with or without the usage of smokeless tobacco and correlate it with clinical parameters.
Materials and Methods: Ninety subjects were divided into three groups of healthy, chronic periodontitis, and smokeless tobacco users with chronic periodontitis from the dental outpatient department of P.M. Nadagouda Memorial Dental College and Hospital. Serum samples of patients were collected after obtaining consent and analyzed for GGT. Statistical Analysis was performed using ANOVA, and Pearson’s correlation coefficient.
Results: GGT levels were found to be significantly higher in chronic periodontitis patients compared to smokeless tobacco users with chronic periodontitis and healthy subjects.
Conclusion: GGT may be used as a quick, easy and precise marker for measuring OS in patients with chronic periodontitis and smokeless tobacco users.
Biomarker, Oxidative stress, Reactive oxygen species
Arati C Koregol, Nagaraj B Kalburgi, Apoorva U Kamat Wagh, Shivraj Warad. GAMMA GLUTAMYL TRANSPEPTIDASE,
SMOKELESS TOBACCO, CHRONIC
PERIODONTITIS: EXPLORING THE LINK. Journal of Clinical and Diagnostic Research [serial online] 2017 March [cited: 2017 May 28 ]; 11:ZC17-ZC20. Available from
Date of Submission: Aug 17, 2016
Date of Peer Review: Oct 19, 2016
Date of Acceptance: Dec 04, 2016
Date of Publishing: Mar 01, 2017
Financial OR OTHER COMPETING INTERESTS: None.
- PubMed Central® (PMC)New
- Academic Search Complete Database
- Chemical Abstracts Service
- Directory of Open Access Journals (DOAJ)
- Embase & EMbiology
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Open J-Gate
- Popline (reproductive health literature)