Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

Users Online : 7463

Original article / research
Year : 2017 | Month : March | Volume : 11 | Issue : 3 | Page : QC25 - QC27

Acute Rubella Virus Infection among Women with Spontaneous Abortion in Mwanza City, Tanzania

Lukombodzo Lulandala, Mariam M Mirambo, Dismas Matovelo, Balthazar Gumodoka, Stephen E Mshana

1. Department of Obstetrics and Gynecology, Weill Bugando School of Medicine, Mwanza, Tanzania. 2. Department of Microbiology and Immunology, Weill Bugando School of Medicine, Mwanza, Tanzania. 3. Department of Obstetrics and Gynecology, Weill Bugando School of Medicine, Mwanza, Tanzania. 4. Professor, Department of Obstetrics and Gynecology, Weill Bugando School of Medicine, Mwanza, Tanzania. 5. Professor, Department of Microbiology and Immunology, Weill Bugando School of Medicine, Mwanza, Tanzania.

Correspondence Address :
Dr. Mariam M. Mirambo,
Department of Microbiology and Immunology, Weill Bugando School of Medicine, Mwanza, Tanzania.
E-mail: mmmirambo@gmail.com

Abstract

Introduction: Acute rubella virus infection in early pregnancy has been associated with poor pregnancy outcome ranging from spontaneous abortion, stillbirth and multiple birth defects known as Congenital Rubella Syndrome (CRS). Despite its importance the prevalence of acute rubella virus infections is not known among women with spontaneous abortion in most centres in developing countries.

Aim: The present study was aimed to determine the seroprevalence of acute rubella infection among women with spontaneous abortion in Mwanza city.

Materials and Methods: A total of 268 women with spontaneous abortion were enrolled from four different hospitals in Mwanza city between November 2015 and April 2016. Blood samples were collected; sera were extracted and stored at -80°C until processing. Acute rubella virus infection was diagnosed by the detection of rubella specific IgM antibodies using indirect Enzyme Linked Immunosorbent Assay (ELISA) as per manufacturer’s instructions. Data were analysed by using STATA version 11.

Results: The mean age of enrolled women was 26.3±5.6 years. The prevalence of acute rubella virus infection was found to be 9/268 (3.7%, 95% CI: 1-5). Only women residing in urban areas (AOR: 5.65, 95% CI: 1.15-27.77, p=0.035) were found to predict acute rubella virus infection among cases with spontaneous abortion in Mwanza city.

Conclusion: About four out of hundred women residing in urban areas with spontaneous abortion in Mwanza are acutely infected with rubella virus highlighting the potential of this virus in contributing to poor pregnancy outcome in this setting.

Keywords

Developing countries, Miscarriage, Rubella specific IgM antibodies

How to cite this article :

Lukombodzo Lulandala, Mariam M Mirambo, Dismas Matovelo, Balthazar Gumodoka, Stephen E Mshana. ACUTE RUBELLA VIRUS INFECTION AMONG WOMEN WITH SPONTANEOUS ABORTION IN MWANZA CITY, TANZANIA. Journal of Clinical and Diagnostic Research [serial online] 2017 March [cited: 2017 Apr 25 ]; 11:QC25-QC27. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=March&volume=11&issue=3&page=QC25-QC27&id=9544

DOI and Others

DOI: 10.7860/JCDR/2017/22634.9544


Date of Submission: Jul 08, 2016
Date of Peer Review: Aug 24, 2016
Date of Acceptance: Sep 20, 2016
Date of Publishing: Mar 01, 2017

Financial OR OTHER COMPETING INTERESTS: None.

JCDR is now Monthly and more widely Indexed .
  • PubMed Central® (PMC)New
  • Academic Search Complete Database
  • Chemical Abstracts Service
  • Directory of Open Access Journals (DOAJ)
  • EBSCOhostNew
  • Embase & EMbiology
  • Google Scholar
  • HINARI Access to Research in Health Programme
  • Indian Science Abstracts (ISA)
  • Journal seek Database
  • Open J-Gate
  • Popline (reproductive health literature)
  • SCOPUS
  • www.omnimedicalsearch.com