Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : March | Volume : 11 | Issue : 3 | Page : OC28 - OC30

The Relationship between Serum Level of Vitamin D3 and the Severity of New Onset Rheumatoid Arthritis Activity

Elham Rajaee, Ali Ghorbani, Karim Mowla, Mehrnoosh Zakerkish, Maryam Mohebi, Mehrdad Dargahi-MalAmir

1. Faculty, Department of Rheumatology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. 2. Associate Professor, Department of Nephrology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. 3. Faculty, Department of Rheumatology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. 4. Faculty, Department of Endocrinology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. 5. Faculty, Department of Internal Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. 6. Faculty, Department of Internal Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Correspondence Address :
Dr. Ali Ghorbani,
Faculty, Department of Nephrology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Khizestan, Iran.

Abstract

Introduction: Rheumatoid Arthritis (RA) is a systemic inflammatory disease which typically involves wrists, ankles, and finally every joint. Some of studies have reported a reverse relationship between the level of vitamin D and RA severity.

Aim: The present study was carried out in order to check the potential relationship between the level of vitamin D and RA severity.

Materials and Methods: Ninety-three patients with RA with onset in recent three months (new onset RA), and 31 patients without RA were chosen as the control group. The patients all aged under 75 years and were diagnosed by a rheumatologist. The serum level of vitamin D was measured through blood test by chemiluminescence method by taking a blood sample of 5 cc. The relationship between the average level of vitamin D and disease severity was analyzed based on scoring scale of DAS28 in different groups with RA. The significant level of the above mentioned tests was set at p<0.05. Data analysis was carried out using SPSS 20.0.

Results: The results of the present study indicated that there was no significant relationship between the two groups in terms of the serum level of vitamin D. Since the subgroups of the patients are not homogenous in terms of age and based on disease severity, ANOVA and chi-square were used to modify this heterogeneity and compare vitamin D levels in patients based on disease severity. The results indicated that there was a significant difference between the three groups of patients in terms of disease severity, such that disease severity rose with a decrease in the serum level of vitamin D, (p-value <0.001).

Conclusion: There was a significant reverse relationship between the serum level of vitamin D and RA severity based on Das Score 28. Therefore, it is recommended that if there is a lack of or insufficient amounts of this vitamin in the body, vitamin D supply needs to be optimized along with other standard medications in order to reduce the RA severity.

Keywords

Disease severity score, Rheumatoid Arthritis severity, Vitamin D

How to cite this article :

Elham Rajaee, Ali Ghorbani, Karim Mowla, Mehrnoosh Zakerkish, Maryam Mohebi, Mehrdad Dargahi-MalAmir. THE RELATIONSHIP BETWEEN SERUM LEVEL OF VITAMIN D3 AND THE SEVERITY OF NEW ONSET RHEUMATOID ARTHRITIS ACTIVITY. Journal of Clinical and Diagnostic Research [serial online] 2017 March [cited: 2017 Mar 26 ]; 11:OC28-OC30. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=March&volume=11&issue=3&page=OC28-OC30&id=9486

DOI and Others

DOI: 10.7860/JCDR/2017/24014.9486

Date of Submission: Sep 07, 2016
Date of Peer Review: Oct 21, 2016
Date of Acceptance: Dec 23, 2016
Date of Publishing: Mar 01, 2017

Financial OR OTHER COMPETING INTERESTS: None.

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