Role of Omega-3 Fatty Acids on Lipid Profile in Diabetic Dyslipidaemia: Single Blind, Randomised Clinical TrialCorrespondence Address :
Dr. Shaylika Chauhan,
Resident Physician, Department of Internal Medicine, Saint Peter’s University Hospital, New Brunswick, New Jersey, USA.
Introduction: Diabetic dyslipidaemia is characterised by hypertriglyceridaemia, low High Density Lipoprotein (HDL), postprandial lipimea, small and dense LDL particles is considered to be a major predisposing factor for various macrovascular complications. Omega-3 fatty acids are fish oil derivative introduced in the market for dyslipidaemia associated with increased triglyceride level.
Aim: To study the effect of omega-3 fatty acids on lipid profile in Type II diabetes patients.
Materials and Methods: This study was prospective, single blind, randomized comparative trial. Hundred patients were randomized into three groups. Group I received metformin 500 mg twice daily and placebo, Group II received metformin 500 mg twice daily and omega-3 fatty acids (1 gram) once daily and the Group III received metformin 500 mg twice daily and omega-3 fatty acids (1 gram) twice daily. ANOVA test was applied for analysis.
Results: Group II was effective in reducing the triglyceride level from 144.59±14.18 mg/dl to 101±13.31 mg/dl which was significant as compared to Group I from 147.67±18.57 mg/dl to 145.8±19.86 mg/dl respectively. Group III containing 1 g of omega-3 fatty acids twice daily showed decrease from 144.83±22.17 mg/dl to 86±17.46 mg/dl and was more effective in reducing triglyceride levels than Group II containing 1 gram of omega-3 fatty acids once daily.
Conclusion: Omega-3 fatty acids can be given in conjunction with metformin to reduce triglyceride levels in diabetic dyslipidaemia without any adverse drug reactions or any drug interaction. Omega-3 fatty acids were effective in reducing the triglyceride level significantly as compared to placebo. Two grams of omega-3 fatty acids were more effective than 1 gram of omega-3 fatty acids in reducing triglyceride levels.
Hypertriglyceridaemia, Postprandial lipimea, Triglyceride
Shaylika Chauhan, Hanish Kodali, Jawad Noor, Karuna Ramteke, Vidisha Gawai. ROLE OF OMEGA-3 FATTY ACIDS ON LIPID
PROFILE IN DIABETIC DYSLIPIDAEMIA: SINGLE
BLIND, RANDOMISED CLINICAL TRIAL. Journal of Clinical and Diagnostic Research [serial online] 2017 March [cited: 2017 May 28 ]; 11:OC13-OC16. Available from
Date of Submission: Apr 09, 2016
Date of Peer Review: Jun 01, 2016
Date of Acceptance: Oct 01, 2016
Date of Publishing: Mar 01, 2017
Financial OR OTHER COMPETING INTERESTS: None.
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