Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Case report
Year : 2017 | Month : March | Volume : 11 | Issue : 3 | Page : FD01 - FD02

Statin Induced Rhabdomyolysis with Non Oliguric Renal Failure: A Rare Presentation

Hashir Kareem, Devavrata Sahu, Mugula Sudhakar Rao, Tom Devasia

1. Associate Professor, Department of Cardiology, KMC Manipal University, Manipal, Karnataka, India. 2. Junior Resident, Department of Cardiology, KMC Manipal University, Manipal, Karnataka, India. 3. Registrar, Department of Cardiology, KMC Manipal University, Manipal, Karnataka, India. 4. Professor, Department of Cardiology, KMC Manipal University, Manipal, Karnataka, India.

Correspondence Address :
Dr. Tom Devasia,
Professor, Department of Cardiology, KMC Manipal University, Manipal-576104, Karnataka, India.
E-mail: drtomdevasia@gmail.com

Abstract

Statins are safe, well tolerated, efficient and time tested drugs for the management of hypercholesterolemia, and thus play a cardinal role in the management of patients with heart disease. Although safe in clinical practice, they are associated with adverse effects, clinically the most important and most severe being muscle related complications/myotoxicity. Rhabdomyolysis, though rare, is the most severe form of myotoxicity. The US Food and Drug Administration (USFDA) adverse event reporting system reports rate of statin induced rhabdomyolysis at 0.3-13.5 cases per 1,000,000 patients. We present a case of a 74-year-old male who presented with an acute coronary syndrome and was initiated on atorvastatin. However, patient developed atorvastatin induced rhabdomyolysis, with non oliguric renal failure, which subsequently improved on cessation of medication.

Keywords

Atorvastatin, Hypercholesterolemia, Myotoxicity

How to cite this article :

Hashir Kareem, Devavrata Sahu, Mugula Sudhakar Rao, Tom Devasia. STATIN INDUCED RHABDOMYOLYSIS WITH NON OLIGURIC RENAL FAILURE: A RARE PRESENTATION. Journal of Clinical and Diagnostic Research [serial online] 2017 March [cited: 2017 Mar 24 ]; 11:FD01-FD02. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=March&volume=11&issue=3&page=FD01-FD02&id=9359

DOI and Others

DOI: 10.7860/JCDR/2017/24491.9359

Date of Submission: Sep 29, 2016
Date of Peer Review: Oct 18, 2016
Date of Acceptance: Nov 08, 2016
Date of Publishing: Mar 01, 2017

Financial OR OTHER COMPETING INTERESTS: None.

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