The Effect of Metformin as an Adjunct Therapy in Adolescents with Type 1 DiabetesCorrespondence Address :
Dr. Azadeh Sayarifard,
Qarib St, Keshavarz Blvd, Tehran-14194, Iran.
E-mail: email@example.com, firstname.lastname@example.org
Introduction: The strict control of blood glucose levels in adolescents with Type 1 Diabetes Mellitus (T1DM) is accompanied with a considerable long term decrease in microvasular and macrovascular complications.
Aim: This study was conducted to investigate the effect of metformin as an adjunct therapy in adolescents with poorly controlled Type 1 diabetes.
Materials and Methods: It was a quasi-experimental (an uncontrolled before and after) study. The study population consisted of the patients aged over 10 years with T1DM. Metformin tablet was added to patient’s insulin therapy for 12 months. Haemoglobin A1c protein was measured in the beginning of the study and repeated with three months intervals till the end of it. Insulin dosage, Body Mass Index (BMI), serum lipid, creatinine and lactate level were measured twice; in the beginning of the study and at the end of it (after 12 months). Data was analysed by SPSS (version 18) software. Paired- t-test, Wilcoxon signed ranks test and Repeated Measure ANOVA were used to examine the study’s hypothesis. A p-value <0.05 was considered as significant.
Results: Twenty nine patients were included in the study. HbA1c level and insulin dosage was significantly reduced (p<0.001) after one month of metformin as an adjunct therapy. Serum lipid was decreased (p=0.7). Weight (p<0.001) and BMI (p=0.007) were increased.
Conclusion: Adjunctive metformin therapy reduced HbA1c value and the insulin dosage received in adolescents with T1DM.
Biguanide, Diabetes Mellitus, Haemoglobin A1c
Aria Setoodeh, Abdollah Didban, Ali Rabbani, Azadeh Sayarifard,
Farzaneh Abbasi, Fatemeh Sayarifard, et al.. THE EFFECT OF METFORMIN AS AN ADJUNCT THERAPY IN ADOLESCENTS WITH TYPE 1 DIABETES. Journal of Clinical and Diagnostic Research [serial online] 2017 April [cited: 2017 Apr 25 ]; 11:SC01-SC04. Available from
Date of Submission: Oct 19, 2016
Date of Peer Review: Nov 17, 2016
Date of Acceptance: Feb 14, 2017
Date of Publishing: Apr 01, 2017
Financial OR OTHER COMPETING INTERESTS: None.
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