Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : April | Volume : 11 | Issue : 4 | Page : PC04 - PC07

Impact of Biliary Calculi on the Liver

Raju Rangaswamy, Chabungbam Gyan Singh, Haobam Manihar Singh, P Punyabati, Kuotho T Nyuwi

1. Junior Resident, Department of General Surgery, Regional Institute of Medical Sciences, Imphal, Manipur, India. 2. Assistant Professor, Department of General Surgery, Regional Institute of Medical Sciences, Imphal, Manipur, India. 3. Professor, Department of General Surgery, Regional Institute of Medical Sciences, Imphal, Manipur, India. 4. Professor, Department of Pathology, Regional Institute of Medical Sciences, Imphal, Manipur, India. 5. Junior Resident, Department of General Surgery, Regional Institute of Medical Sciences, Imphal, Manipur, India.

Correspondence Address :
Dr. Chabungbam Gyan Singh,
Assistant Professor, Department of Surgery, Regional Institute of Medical Sciences, Imphal-795004, Manipur, India.
E-mail: drgyan2006@yahoo.co.in

Abstract

Introduction: Gallstone is implicated for hepatocellular injury due to chronic extra hepatic large bile duct obstruction with or without repeated episodes of cholangitis.

Aim: To study the liver changes in patients undergoing operative procedure for gallstone disease and to determine the relationship between severity of these changes with position of biliary calculus in biliary tree.

Materials and Methods: Sixty patients who underwent operative procedure for gallstone disease between October 2013 and September 2015 were evaluated. The Liver Function Test (LFT) was done preoperatively and postoperatively. Intraoperative liver biopsy was taken. The histopathological changes of liver and their severity were noted.

Results: The most commonly observed liver function abnormality both in cholelithiasis (12.8%) and choledocholithiasis patients (50%) was increased alkaline phosphatase. Most commonly observed liver histology changes in patients with cholelithiasis was nonspecific reactive hepatitis (46.9%) and in choledocholithiasis was chronic cholestasis (50%). Patient with choledocholithiasis showed significant changes (p<0.001) in liver histopathology and LFT as compared to cholelithiasis.

Conclusion: Patients with gallstone diseases developed significant functional as well as structural hepatic changes. Though the change was more significant in patient with choledocholithiasis compared to cholelithiasis, early operative procedure is recommended in all gallstone disease patients to prevent potential liver damage, irrespective of position of biliary calculi in biliary tree to prevent morbidities associated with it.

Keywords

Cholangitis, Cholelithiasis, Choledocholithiasis, Gallstone, Hepatocellular injury

How to cite this article :

Raju Rangaswamy, Chabungbam Gyan Singh, Haobam Manihar Singh, P Punyabati, Kuotho T Nyuwi. IMPACT OF BILIARY CALCULI ON THE LIVER. Journal of Clinical and Diagnostic Research [serial online] 2017 April [cited: 2017 May 30 ]; 11:PC04-PC07. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=April&volume=11&issue=4&page=PC04-PC07&id=9738

DOI and Others

DOI: 10.7860/JCDR/2017/24680.9738


Date of Submission: Oct 07, 2016
Date of Peer Review: Dec 05, 2016
Date of Acceptance: Feb 20, 2017
Date of Publishing: Apr 01, 2017

Financial OR OTHER COMPETING INTERESTS: None.

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