Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Case report
Year : 2017 | Month : April | Volume : 11 | Issue : 4 | Page : OD05 - OD07

Recurrent Longitudinally Extensive Myelitis and Aquaporin-4 Seronegativity – The Expanding Spectrum of Neuromyelitis Optica

Ravi Anadure, Coimbatore Sivasubramanian Narayanan, Govindaraj Varadraj

Dr. Ravi Anadure, Senior Advisor, Division of Neurology, Department of Medicine, INHS Asvini, Colaba, Mumbai-400005, Maharashtra, India. E-mail: ravi.anadure@gmail.com

Correspondence Address :
Dr. Ravi Anadure,
Senior Advisor, Division of Neurology, Department of Medicine, INHS Asvini,
Colaba, Mumbai-400005, Maharashtra, India.
E-mail: ravi.anadure@gmail.com

Abstract

Neuromyelitis Optica Spectrum Disorder (NMOSD) is a recently proposed unifying term for Neuromyelitis Optica (NMO), also known as Devic's disease and related syndromes. It is a relapsing inflammatory demyelinating disease that most commonly affects optic nerves and the spinal cord, leading to sudden vision loss or weakness in one or both eyes, and loss of sensation and bladder function. Though inflammation may also involve the brain, the lesions seen in NMO are different from Multiple Sclerosis (MS) which has a similar clinical course. Attacks of NMOSD tend to be more severe and often different in nature from MS. MS and NMOSD are often confused but require a different course of treatment for optimal results. Here, we describe a patient who had clinical features suggestive of NMO but showed seronegativity for anti-aquaporin antibodies, done twice. Initially he was managed on the lines of MS but showed a deteriorating clinical course on initiation of treatment with interferons. Later, his diagnosis was revised to seronegative NMO and he was started on immunosuppressive therapy with azathioprine to which he showed optimal response and achieved disease stabilization.

Keywords

Multiple sclerosis, Optic nerves, Spinal cord

How to cite this article :

Ravi Anadure, Coimbatore Sivasubramanian Narayanan, Govindaraj Varadraj. RECURRENT LONGITUDINALLY EXTENSIVE MYELITIS AND AQUAPORIN-4 SERONEGATIVITY – THE EXPANDING SPECTRUM OF NEUROMYELITIS OPTICA. Journal of Clinical and Diagnostic Research [serial online] 2017 April [cited: 2017 Apr 25 ]; 11:OD05-OD07. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=April&volume=11&issue=4&page=OD05-OD07&id=9564

DOI and Others

DOI: 10.7860/JCDR/2017/24186.9564

Date of Submission: Sep 14, 2016
Date of Peer Review: Dec 08, 2016
Date of Acceptance: Jan 06, 2017
Date of Publishing: Apr 01, 2017

Financial OR OTHER COMPETING INTERESTS: None.

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