Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : April | Volume : 11 | Issue : 4 | Page : EC15 - EC20

Histopathological Study of Central Nervous System Lesions: Emphasizing Association of Neoplasms with ABO Blood Groups

B.N. Kumarguru, P. Pallavi, Sunila, G.V. Manjunath, T.S. Vasan, B.R. Rajalakshmi

1. Assistant Professor, Department of Pathology, P.E.S. Institute of Medical Sciences and Research, Kuppam, Andhra Pradesh, India. 2. Associate Professor, Department of Pathology, JSS Medical College, Mysore, Karnataka, India. 3. Professor, Department of Pathology, JSS Medical College, Mysore, Karnataka, India. 4. Vice Principal, Former Professor and Head, Department of Pathology, JSS Medical College, Mysore, Karnataka, India. 5. Associate Professor, Department of Neurosurgery, JSS Medical College, Mysore, Karnataka, India. 6. Assistant Professor, Department of Pathology, JSS Medical College, Mysore, Karnataka, India.

Correspondence Address :
Dr. B.N. Kumarguru,
Assistant Professor, Department of Pathology, PESIMSR, Kuppam-517425, Andhra Pradesh, India.
E-mail: kumarguru1978@yahoo.com

Abstract

Introduction: The Central Nervous System (CNS) lesions show considerable geographic and racial variations with respect to the incidence and the pattern of distribution of lesions. The ABO blood status is a readily accessible factor in genetic constitution of the patients. It has been shown to be associated with many diseases. But the influence of blood group status on the pathogenesis of brain tumours is still unclear.

Aim: To study various histopathological patterns of CNS lesions and to evaluate the association of CNS tumours with the distribution of ABO blood groups in documented cases.

Materials and Methods: In the present study, 147 cases were analyzed. It was an analytical type of study, done at JSS Medical College, Mysore, over a period of 2 years and 8 months from January 2009 to August 2011. Histopathology slides were routinely stained by Haematoxylin and Eosin (H&E) stain. Special stains were performed in selected cases. Blood group of the patients and the control group were documented. Blood group distribution pattern was assessed in relation to histopathological diagnosis of various CNS tumours.

Results: Histopathological diagnosis of 147 cases included neoplastic lesions (84.35%) and non-neoplastic lesions (15.64%). Neoplastic lesions (84.35%) constituted the majority, which included neuroepithelial tumours (29.25%) as predominant pattern. Non--neoplastic lesions constituted only 15.64%, which included inflammatory lesion (8.16%) as the predominant pattern. ABO blood group data was available in 92 cases (84.4%) of neoplastic lesions, which included 71 cases (48.29%) of primary CNS neoplasms categorized according to WHO grades. The control group constituted 21,067 healthy voluntary donors. Blood group O was the most frequent blood group in neoplastic lesions (40.21%) and primary CNS neoplasms categorized according to WHO grades (45.07%). The association between the CNS neoplasms and ABO blood groups was not statistically significant (p = 0.055). But a definite change in the pattern of distribution of ABO blood groups observed between neoplastic lesions and control groups.

Conclusion: The influence of blood group types on the development of brain tumours appears intriguing and needs to be well established. Though statistically insignificant, a definite change in the pattern of distribution of ABO blood groups was observed between neoplastic lesions and control groups. This necessitates attention and stratification of patients for effective management.

Keywords

Brain tumours, Donors, Neuroepithelial tumours

How to cite this article :

B.N. Kumarguru, P. Pallavi, Sunila, G.V. Manjunath, T.S. Vasan, B.R. Rajalakshmi. HISTOPATHOLOGICAL STUDY OF CENTRAL NERVOUS SYSTEM LESIONS: EMPHASIZING ASSOCIATION OF NEOPLASMS WITH ABO BLOOD GROUPS. Journal of Clinical and Diagnostic Research [serial online] 2017 April [cited: 2017 May 27 ]; 11:EC15-EC20. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=April&volume=11&issue=4&page=EC15-EC20&id=9644

DOI and Others

DOI: 10.7860/JCDR/2017/23863.9644


Date of Submission: Sep 01, 2016
Date of Peer Review: Oct 19, 2016
Date of Acceptance: Jan 10, 2017
Date of Publishing: Apr 01, 2017

Financial OR OTHER COMPETING INTERESTS: None.

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