Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : April | Volume : 11 | Issue : 4 | Page : CC13 - CC15

Correlation of Body Mass Index (BMI) with Thyroid Function in Euthyroid Pregnant Women in Manipur, India

Sumit Kumar, T. Chiinngaihlun, M. Rameswar Singh, O. Punyabati

1. Postgraduate Trainee, Department of Physiology, Regional Institute of Medical Sciences (RIMS), Imphal, Manipur, India. 2. Postgraduate Trainee, Department of Physiology, Regional Institute of Medical Sciences (RIMS), Imphal, Manipur, India. 3. Associate Professor, Department of Obstetrics and Gynaecology, Regional Institute of Medical Sciences (RIMS), Imphal, Manipur, India. 4. Professor, Department of Physiology, Regional Institute of Medical Sciences (RIMS), Imphal, Manipur, India.

Correspondence Address :
Dr. Sumit Kumar,
S/O Sri Chandra Bhushan Kumar Sinha, Opp. Reliance Tower, Chanakya Colony,
P.O: Industrial Area, Hajipur, Bihar-844101, India.
E-mail: drsumitkumar27@gmail.com

Abstract

Introduction: Body Mass Index (BMI) is significantly increased during pregnancy due to gain of weight with normal progression of pregnancy. The exact influences of thyroid function on BMI are ill defined in euthyroid pregnant women.

Aim: To correlate serum levels of Free Triiodothyronine (FT3), Free Thyroxine (FT4) and Thyroid Stimulating Hormone (TSH) level with BMI of participant normal pregnant women in all the three trimesters.

Materials and Methods: In this cross-sectional comparative study, total of 210 healthy pregnant women comprising of 70 participants in each trimester, attending Obstetrics Outpatient Department (OPD) for antenatal check-up were consecutively selected. Estimation of serum FT3, FT4 and TSH level was done by ELISA based methods. The Correlation of BMI with serum levels of FT3, FT4 and TSH was done using Pearson correlation test (r) by SPSS version 21.0 software.

Results: TSH level of participant normal pregnant women showed significant positive correlation with BMI during first (r=0.254 and p=0.034) and second trimester (r=0.263 and p=0.028) of pregnancy. FT4 level showed significant negative correlation in second (r= -0.454 and p<0.001) and third trimester (r= -0.351 and p=0.003) of pregnancy. Correlation between BMI and FT3 level showed no significant association in any of the trimesters.

Conclusion: BMI correlates positively with TSH level in first and second trimesters while it correlates negatively with FT4 level in second and third trimesters, but, failed to demonstrate significant association with FT3 level in any of trimesters in euthyroid pregnant women. Serum TSH along with FT4 level appears more useful modality compared to serum TSH alone for targeted thyroid screening particularly in obese pregnant women.

Keywords

Free thyroxine, Thyroid gland, Thyrotropin

How to cite this article :

Sumit Kumar, T. Chiinngaihlun, M. Rameswar Singh, O. Punyabati. CORRELATION OF BODY MASS INDEX (BMI) WITH THYROID FUNCTION IN EUTHYROID PREGNANT WOMEN IN MANIPUR, INDIA. Journal of Clinical and Diagnostic Research [serial online] 2017 April [cited: 2017 Apr 25 ]; 11:CC13-CC15. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=April&volume=11&issue=4&page=CC13-CC15&id=9726

DOI and Others

DOI: 10.7860/JCDR/2017/25258.9726

Date of Submission: Nov 06, 2016
Date of Peer Review: Jan 05, 2017
Date of Acceptance: Jan 10, 2017
Date of Publishing: Apr 01, 2017

Financial OR OTHER COMPETING INTERESTS: None.

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