Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : April | Volume : 11 | Issue : 4 | Page : BC18 - BC22

Effect of DOTS Treatment on Vitamin D Levels in Pulmonary Tuberculosis

Akshatha Lalesh Naik, Madan Gopal Rajan, Poornima A. Manjrekar, Mamatha T. Shenoy, Souparnika Shreelata, Rukmini Mysore Srikantiah, Anupama Hegde

1. Assistant Professor, Department of Biochemistry, Shridevi Institute of Medical Sciences and Research Hospital, Tumkur, Karnataka, India. 2. Assistant Professor, Department of Biochemistry, AJ Institute of Medical Sciences, Mangalore, Karnataka, India. 3. Professor and Head, Department of Biochemistry, Kasturba Medical College, Mangalore, karnataka, India. 4. Assistant Professor, Department of Biochemistry, KVG Medical College and Hospital, Sullia, Karnataka, India. 5. Junior Research Fellow, Department of Biochemistry, Kasturba Medical College, Mangalore, Karnataka, India. 6. Associate Professor, Department of Biochemistry, Kasturba Medical College, Mangalore, Karnataka, India. 7. Associate Professor, Department of Biochemistry, Kasturba Medical College, Mangalore, Karnataka, India.

Correspondence Address :
Dr. Poornima A Manjrekar,
Professor and Head, Department of Biochemistry, Kasturba Medical College, Mangalore-572106, Karnataka, India.
E-mail: aksh015@gmail.com

Abstract

Introduction: Vitamin D (Vit D) modulates a variety of processes and regulatory systems including host defense, inflammation, immunity, and repair. Vit D Deficiency (VDD) is been implicated as a cause in diabetes, immune dysfunction and Tuberculosis (TB). Impaired metabolism of Vit D and an adverse outcome is associated with Pulmonary Tuberculosis (PTB). Directly Observed Treatment Short Course (DOTS) consist of drugs like rifampicin and isoniazid, which respectively cause accelerated loss of Vit D due to increased clearance and impairment of 25- hydroxylation causing diminished Vit D action.

Aim: The aim of the present study was to estimate and compare serum Vit D status in newly diagnosed PTB patients before and after DOTS to validate the supplementation of Vit D in PTB patients.

Materials and Methods: Forty four newly diagnosed PTB patients of both the sexes in the age group of 18 to 60 years before starting DOTS were recruited to participate in this nonrandomized controlled trial with their voluntary consent. Vit D status in these patients and the effect of DOTS on Vit D were evaluated.

Results: Mean Vit D levels of the study population aged 4313 years was 20.74 ng/ml (normal >30 ng/ml) at the time of diagnosis. After completion of six months of therapy mean Vit D reduced to 17.49 ng/ml (p-value=0.041). On individual observations, 70% of the participants showed a decrease in Vit D levels from their baseline, whereas 30% showed an increase. Comparison between the two groups indicated the possible role of younger age in the improved status.

Conclusion: VDD was seen in PTB patients, which worsened in majority of the study population after treatment; hence it would be advisable to recommend Vit D supplementation in PTB patients for a better outcome.

Keywords

Hepatoxity, Nutritional deficiency, Vitamin D supplementation

DOI and Others

DOI: 10.7860/JCDR/2017/24501.9759

Date of Submission: Sep 29, 2016
Date of Peer Review: Dec 08, 2016
Date of Acceptance: Feb 05, 2017
Date of Publishing: Apr 01, 2017

Financial OR OTHER COMPETING INTERESTS: None.

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