Comparative Evaluation of Antimicrobial Activity of QMiX, 2.5% Sodium Hypochlorite, 2% Chlorhexidine, Guava Leaf Extract and Aloevera Extract Against Enterococcus faecalis and Candida albicans – An in-vitro StudyCorrespondence Address :
Dr. Jerin Jose,
Junior Resident, Department of Conservative Dentistry and Endodontics, Government Dental College,
Kottayam-686008, Kerala, India.
Introduction: Debridement and disinfection of the root canal system is a critical step in endodontic treatment. Most of the irrigants presently used in the endodontic treatment can have an impact on the microbes surviving in the biofilm but none of them are able to do all of the required tasks. Researches are going on its full swing in order to produce an endodontic irrigant having ideal properties.
Aim: To compare the antimicrobial efficacy of different irrigants like QMiX, guava leaf extract, aloevera extract, 2.5% sodium hypochlorite and 2% chlorhexidine gluconate against Enterococcus faecalis and Candida albicans.
Materials and Methods: The antimicrobial activity was determined using agar diffusion test. The solutions were divided into five groups: Group I- QMiX, Group II- Guava leaf extract and Group III-Aloevera extract, Group IV–2.5% Sodium hypochlorite and Group V-2% Chlorhexidine. The zones of inhibition of growth were recorded.
Results: Statistical analysis was performed using one way ANOVA with post-hoc Tukey’s HSD. Values obtained were statistically analyzed (p<0.05). QMiX showed maximum inhibitory effect against Enterococcus faecalis and Candida albicans followed by, 2% chlorhexidine, 2.5% sodium hypochlorite, guava leaf extract and aloevera extract. Results obtained were statistically significant.
Conclusion: Guava leaf extract showed significant inhibitory effects against Enterococcus faecalis and Candida albicans. QMiX demonstrated the best results among the tested solutions and can be considered as a potential alternative to existing root canal irrigants.
Antimicrobial efficacy, Microbial infection, Root canal irrigation
Jerin Jose, Shoba Krishnamma, Faizal Peedikayil, Shibu Aman, Nithya Tomy, Jithin Pulickal Mariodan. COMPARATIVE EVALUATION OF ANTIMICROBIAL ACTIVITY OF QMIX, 2.5% SODIUM HYPOCHLORITE, 2% CHLORHEXIDINE, GUAVA LEAF EXTRACT AND ALOEVERA EXTRACT AGAINST ENTEROCOCCUS FAECALIS AND CANDIDA ALBICANS – AN IN-VITRO STUDY. Journal of Clinical and Diagnostic Research [serial online] 2016 May [cited: 2018 Jan 17 ]; 10:ZC20-ZC23. Available from
Date of Submission: Nov 16, 2015
Date of Peer Review: Jan 22, 2016
Date of Acceptance: Feb 04, 2016
Date of Publishing: May 01, 2016
Financial OR OTHER COMPETING INTERESTS: None.
- Emerging Sources Citation Index (Web of Science, thomsonreuters)
- Index Copernicus ICV 2016: 132.37
- Academic Search Complete Database
- Directory of Open Access Journals (DOAJ)
- Embase & EMbiology
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Popline (reproductive health literature)