Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2016 | Month : May | Volume : 10 | Issue : 5 | Page : OC32 - OC36

Effect of Atorvastatin on the Disease Activity and Severity of Rheumatoid Arthritis: Double-Blind Randomized Controlled Trial

Karim Mowla, Elham Rajai, Ali Ghorbani, Mehrdad Dargahi-MalAmir, Mohammad Bahadoram, Shooka Mohammadi

1. Faculty, Department of Rheumatology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. 2. Faculty, Department of Rheumatology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. 3. Faculty, Department of Nephrology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. 4. Faculty, Department of Internal Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. 5. Medical Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. 6. Dietetics and Nutritional Sciences Programmes, School of Healthcare Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

Correspondence Address :
Dr. Mehrdad Dargahi-Malamir,
Department of Internal Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
E-mail: mohammadbahadoram@yahoo.com

Abstract

Introduction: HMG-CoA (3-hydroxy-3- methylglutary lcoenzyme A) reductase inhibitors (statins) have anti-inflammatory properties which may be particularly useful in rheumatoid arthritis to suppress disease activity and inflammatory factors.

Aim: The purpose of this clinical trial was to determine anti-inflammatory properties of statins in rheumatoid arthritis.

Materials and Methods: Eighty Iranian patients with rheumatoid arthritis, aged between 19 to 75 years were recruited to take part in this randomized, double-blind placebo-controlled trial. Subjects were randomly allocated to two groups to take atorvastatin or placebo 40 mg daily as an adjunct to current disease-modifying anti-rheumatic drugs (DMARDs) treatment. Disease Activity Score-28 (DAS28), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), swollen joint count (SJC) & tender joint count (TJC) were assessed before and after three months intervention.

Results: Analysis was based on intention to treat. DAS28 significantly declined in the atorvastatin group in comparison with placebo (p< 0.001). SJC, TJC, CRP and ESR also were significantly dropped in the atorvastatin group in comparison with placebo.

Conclusion: It can be concluded that atorvastatin can suppress RA activity and inflmmatory factors in RA patients for high to moderate grade of inflmmation.

Keywords

HMG-CoA, Anti-inflammatory agents, Erythrocyte sedimentation rate, Swollen joint count, Tender joint count

How to cite this article :

Karim Mowla, Elham Rajai, Ali Ghorbani, Mehrdad Dargahi-MalAmir, Mohammad Bahadoram, Shooka Mohammadi. EFFECT OF ATORVASTATIN ON THE DISEASE ACTIVITY AND SEVERITY OF RHEUMATOID ARTHRITIS: DOUBLE-BLIND RANDOMIZED CONTROLLED TRIAL. Journal of Clinical and Diagnostic Research [serial online] 2016 May [cited: 2018 Apr 23 ]; 10:OC32-OC36. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2016&month=May&volume=10&issue=5&page=OC32-OC36&id=7814

DOI and Others

DOI: 10.7860/JCDR/2016/16538.7814


Date of Submission: Aug 29, 2015
Date of Peer Review: Oct 20, 2015
Date of Acceptance: Dec 30, 2015
Date of Publishing: May 01, 2016

Financial OR OTHER COMPETING INTERESTS: As Declared above.

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