Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

Users Online : 14437

Case report
Year : 2016 | Month : May | Volume : 10 | Issue : 5 | Page : ND04 - ND05

Chronic Myeloid Leukaemia Presenting as Bilateral Retinal Haemorrhages with Multiple Retinal Infiltrates

Priyanka Ramkrishna Rane, Rakesh K. Barot, Devadatta Jayantilal Gohel, Nupur Bhagat

1. Registrar, Department of Ophthalmology, Rajiv Gandhi Medical College and Chhatrapati Shivaji Hospital, Kalwa, India. 2. Associate Professor and Head of Department, Department of Ophthalmology, Rajiv Gandhi Medical College and Chhatrapati Shivaji Hospital, Kalwa, India. 3. Professor and Head of Department, Department of Ophthalmology, Shri M.P. Shah Government College and Guru Gobind Singh Hospital, Jamnagar, India. 4. Registrar, Department of Ophthalmology, Rajiv Gandhi Medical College and Chhatrapati Shivaji Hospital, Kalwa, India.

Correspondence Address :
Dr. Priyanka Ramkrishna Rane,
B-3, Rudraksh C.H.S, Plot No.16,Sector-7,Airoli, Navi Mumbai-400708, India.
E-mail: priyankarrane@yahoo.com

Abstract

Chronic Myeloid Leukaemia (CML) causes retinopathy manifesting as venous dilation and tortuosity, perivascular sheathing, retinal haemorrhages, microaneurysms, cotton-wool spots and optic nerve infiltration. Retina is the most commonly involved intraocular structure in CML. However, retinal involvement is a rare form of presentation of CML and few cases have been reported. We report a case of CML presenting as unilateral sudden visual loss. Fundus showed multiple white centered retinal haemorrhages in both eyes with unilateral macular oedema. Blood work-up showed raised WBC count, high platelet count and low Haemoglobin. Cytological analysis of bone marrow biopsy confirmed Philadelphia chromosome. After a course of Imatinib, visual acuity improved and haemorrhages resolved with normalization of macular thickness. In our case, patient presented early, leading to early detection producing better visual prognosis. This highlights the importance of detailed hematological work up in patients with retinal involvement to rule out leukaemic retinopathy.

Keywords

Leukaemic infiltration, Macular oedema, Imatinib

How to cite this article :

Priyanka Ramkrishna Rane, Rakesh K. Barot, Devadatta Jayantilal Gohel, Nupur Bhagat. CHRONIC MYELOID LEUKAEMIA PRESENTING AS BILATERAL RETINAL HAEMORRHAGES WITH MULTIPLE RETINAL INFILTRATES. Journal of Clinical and Diagnostic Research [serial online] 2016 May [cited: 2018 Jul 19 ]; 10:ND04-ND05. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2016&month=May&volume=10&issue=5&page=ND04-ND05&id=7822

DOI and Others

DOI: 10.7860/JCDR/2016/18215.7822

Date of Submission: Dec 08, 2015
Date of Peer Review: Jan 11, 2016
Date of Acceptance: Feb 24, 2016
Date of Publishing: May 01, 2016

Financial OR OTHER COMPETING INTERESTS: None.

JCDR is now Monthly and more widely Indexed .
  • Emerging Sources Citation Index (Web of Science, thomsonreuters)
  • Index Copernicus ICV 2016: 132.37
  • SCOPUS
  • Academic Search Complete Database
  • Directory of Open Access Journals (DOAJ)
  • EBSCOhost
  • Embase & EMbiology
  • Google Scholar
  • HINARI Access to Research in Health Programme
  • Indian Science Abstracts (ISA)
  • Journal seek Database
  • Google
  • Popline (reproductive health literature)
  • www.omnimedicalsearch.com