Chronic Myeloid Leukaemia Presenting as Bilateral Retinal Haemorrhages with Multiple Retinal InfiltratesCorrespondence Address :
Dr. Priyanka Ramkrishna Rane,
B-3, Rudraksh C.H.S, Plot No.16,Sector-7,Airoli, Navi Mumbai-400708, India.
Chronic Myeloid Leukaemia (CML) causes retinopathy manifesting as venous dilation and tortuosity, perivascular sheathing, retinal haemorrhages, microaneurysms, cotton-wool spots and optic nerve infiltration. Retina is the most commonly involved intraocular structure in CML. However, retinal involvement is a rare form of presentation of CML and few cases have been reported. We report a case of CML presenting as unilateral sudden visual loss. Fundus showed multiple white centered retinal haemorrhages in both eyes with unilateral macular oedema. Blood work-up showed raised WBC count, high platelet count and low Haemoglobin. Cytological analysis of bone marrow biopsy confirmed Philadelphia chromosome. After a course of Imatinib, visual acuity improved and haemorrhages resolved with normalization of macular thickness. In our case, patient presented early, leading to early detection producing better visual prognosis. This highlights the importance of detailed hematological work up in patients with retinal involvement to rule out leukaemic retinopathy.
Leukaemic infiltration, Macular oedema, Imatinib
Priyanka Ramkrishna Rane, Rakesh K. Barot, Devadatta Jayantilal Gohel, Nupur Bhagat. CHRONIC MYELOID LEUKAEMIA PRESENTING
AS BILATERAL RETINAL HAEMORRHAGES
WITH MULTIPLE RETINAL INFILTRATES. Journal of Clinical and Diagnostic Research [serial online] 2016 May [cited: 2018 Jul 19 ]; 10:ND04-ND05. Available from
Date of Submission: Dec 08, 2015
Date of Peer Review: Jan 11, 2016
Date of Acceptance: Feb 24, 2016
Date of Publishing: May 01, 2016
Financial OR OTHER COMPETING INTERESTS: None.
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