Zinc Levels in Seminal Fluid in Infertile Males and its Relation with Serum Free TestosteroneCorrespondence Address :
Dr. Radhika Purushottam Kothari,
Tutor, Department of Physiology, Mahatma Gandhi Institute of Medical Sciences,
Sevagram, Wardha-442102, Maharashtra, India.
Introduction: The role of zinc is critical to reproduction potential. Seminal zinc is thought to be derived almost exclusively from prostatic secretions. Sperm motility is significantly influenced by zinc. Zinc deficiency has been linked with male sterility and subfertility.
Aim: To assess the influence of seminal plasma zinc on seminogram characteristics and whether endogenous testosterone affects the seminal levels of zinc.
Materials and Methods: The semen samples were obtained from 150 male partners of infertile couples who attended the Reproductive Biology Unit of the Department of Physiology, within the age 21-50 years and semen samples were analysed for the routine seminogram parameters. All the subjects were classified into two main groups, A- the subjects with normal ejaculates (n=62) and B- the subjects with abnormal ejaculates, who were further sub divided into the following groups: i) Asthenoteratozoospermics (n=43); ii) Oligoasthenoteratozoospermics (n=24); and iii) Azoospermics (n=21). The seminal plasma zinc was measured spectrophotometrically. The sample for serum free testosterone was sent to Thyrocare laboratory.
Results: The seminal plasma zinc was found to be significantly lower in the abnormal ejaculates than in the normal ejaculates. A statistically significant positive correlation was observed between the seminal plasma zinc and serum free testosterone (p<0.05, r=0.449). Statistically significant correlation was also found between seminal plasma zinc and all the seminogram parameters such as the sperm concentration, sperm motility and sperm morphology (p<0.05, r= 0.86, 0.87 and 0.86 respectively).
Conclusion: Low seminal plasma zinc might be a significant causative factor in impairing sperm functions and its dependence on endogenous free testosterone, was observed from a positive correlation between the two.
Male infertility, Seminal zinc, Seminogram, Spectrophotometric method
Radhika Purushottam Kothari, Ajay Rajeshwar Chaudhari. ZINC LEVELS IN SEMINAL FLUID IN
INFERTILE MALES AND ITS RELATION
WITH SERUM FREE TESTOSTERONE. Journal of Clinical and Diagnostic Research [serial online] 2016 May [cited: 2018 Jan 20 ]; 10:CC05-CC08. Available from
Date of Submission: Apr 09, 2015
Date of Peer Review: Jul 01, 2015
Date of Acceptance: Aug 26, 2015
Date of Publishing: May 01, 2016
Financial OR OTHER COMPETING INTERESTS: None.
- Emerging Sources Citation Index (Web of Science, thomsonreuters)
- Index Copernicus ICV 2016: 132.37
- Academic Search Complete Database
- Directory of Open Access Journals (DOAJ)
- Embase & EMbiology
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Popline (reproductive health literature)