Immunoglobulin E, Interleukin-18 and Interleukin-12 in Patients with Atopic Dermatitis: Correlation with Disease Activity
Correspondence Address :
Dr. Zafar Rasheed,
Assistant Professor, Department of Medical Biochemistry, College of Medicine, Qassim University,
P.O. Box 30109, Buraidah 51452, Saudi Arabia.
E-mail: zafarrasheed@qumed.edu.sa
Introduction: Atopic dermatitis (AD) is a chronic inflammatory skin disorder. Immunological/inflammatory reactions are reported to play a role in AD but their role in disease activity has not been fully investigated. This study was done to investigate the role of immunoglobulin E (IgE), interleukin (IL)-18 and IL-12 in AD patients with different disease severities.
Materials and Methods: Sera from 50 AD infants with varying levels of disease activity according to the scoring index of atopic dermatitis (SCORAD) index and 30 age-matched healthy controls were evaluated for serum levels of IgE, IL-18 and IL-12/p40.
Results: Serum analysis showed higher levels of IgE, IL-18 or IL-12/p40 in AD patients compared with controls. Interestingly, not only was there an increased number of subjects positive for IgE, IL-18 or IL-12/p40, but also the levels of these parameters were higher among AD patients whose SCORAD scores were higher. In addition, a significant correlation was observed between the levels of these parameters and SCORAD scores.
Conclusion: These findings support an association between IgE, IL-18 or IL-12/p40 and AD. The stronger response observed in serum samples from patients with higher SCORAD scores suggest that IgE, IL-18 and IL-12/p40 may be useful in evaluating the progression of AD and in elucidating the mechanisms of disease pathogenesis.
Atopic dermatitis, Disease activity, Immunoglobulin E, Interleukin-18, Interleukin-12
DOI: 10.7860/JCDR/2015/12261.5742
Date of Submission: Nov 24, 2014
Date of Peer Review: Feb 21, 2015
Date of Acceptance: Feb 28, 2015
Date of Publishing: Apr 01, 2015
Financial OR OTHER COMPETING INTERESTS: As declared above.
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