Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Case report
Table of Contents - Year : 2017 | Month : June | Volume : 11 | Issue : 6 | Page : ZD14 - ZD15

Infantile Alexander Disease: Case Report and Review of Literature ZD14-ZD15

Soumyabrata Sarkar, Rupam Sinha, Amitabha Chakraborty, Tanya Khaitan, Biyas Bhowmik

Dr. Soumyabrata Sarkar,
Reader, Department of Oral Medicine and Radiology, Haldia Institute of Dental sciences and Research,
Haldia, West Bengal 721645, India.

Alexander Disease (AD) is an autosomal dominant leukodystrophy and occurs predominantly in infants and children. It usually results in death within ten years after onset. Among the four subtypes, infantile form comprises the most of affected individuals. It presents in the first two years of life, typically with progressive psychomotor deficiency, loss of developmental milestones, seizures, and pyramidal signs. Clinical and magnetic resonance image findings usually establish diagnosis of AD. Here, we present a case of Infantile AD with characteristic clinical and radiological features.