Cefoperazone Induced Gastrointestinal Bleeding OD10-OD11
Dr. Goutham Reddy Katukuri,
Flat no. 203, Shambavi Classic Apartments, Vidyaratna Nagar, Manipal, Udupi-576104, Karnataka, India.
Cefoperazone is a beta-lactam antibiotic which is frequently used in treating a variety of gram positive and gram negative infections. The chemical structure of cefoperazone contains a side chain of N-methylthiotetrazole which can inhibit vitamin K metabolism resulting in hypoprothombinemia. We report a case of cefoperazone induced coagulopathy manifesting as gastrointestinal bleeding. A Naranjo assessment score of 5 was obtained, indicating a probable relationship between the patientís coagulation function disorder and her use of the suspect drug.