Comparative Efficacy and Safety of Triple Therapy (Ramipril, Telmisartan, Hydrochlorothiazide) Vs Dual Anti Hypertensive Therapy (Ramipril or Telmisartan, Hydrochlorothiazide) in Stage 2 Hypertensive Patients
HC25-HC28
Correspondence
Dr. Bharat Bhushan,
H.No. F-65, Upper Krishna Nagar, Near Resham Ghar Colony, Jammu 180016, India.
Phone : 9086065555, 9858911910, E-mail : bharat4rl@yahoo.com
Aim: To evaluate the comparative efficacy and safety of ramipril 5mg plus hydrochlorothiazide 12.5mg (R + HCTZ), telmisartan 40mg plus hydrochlorothiazide12.5mg (T + HCTZ) and ramipril 2.5mg plus telmisartan 20mg plus hydrochlorothiazide12.5mg (R + T + HCTZ) in patients with stage 2 hypertension.
Material and Methods: A prospective, open label, randomized comparative study was conducted to study the comparative efficacy and safety of R+HCTZ (group 1), T+HCTZ ( group 2) and R+T+TCTZ (group3) in eighty eight patients with stage 2 hypertension without co morbid conditions. Echocardiography was done to assess left ventricular function. Patients were followed up to 24 weeks and any ADR occurring in this period was recorded.
Results: All the three treatment groups showed significant fall in both systolic and diastolic blood pressure compared to the baseline scores (p<0.0001).Intergroup comparison did not reveal any significant difference .Total number of adverse drug events reported were fifteen . Group III had higher percentage ADRs . Dry cough (8) was most common ADR . The echocardiography parameters did not change from baseline values with all three treatment regimens .
Conclusion: All three medications were of equal efficacy in patients with stage 2 hypertension without co morbid conditions, failing to prove superiority over each other.